Phenotypes associated with this allele

• Allele Symbol: Dvl2^tm1.2Wds
• Allele Name: targeted mutation 1.2, William D Snider
• Allele ID: MGI:7531373
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dvl2^tm1.2Wds/Dvl2^tm1.2Wds	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA	MGI:7531376
cx2	Dvl2^tm1.2Wds/Dvl2^+ Shroom3^Gt(ROSA53)Sor/Shroom3^+	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA	MGI:7560660
cx3	Dvl2^tm1.2Wds/Dvl2^tm1.2Wds Shroom3^Gt(ROSA53)Sor/Shroom3^Gt(ROSA53)Sor	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA	MGI:7560661
cx4	Dvl2^tm1.2Wds/Dvl2^+ Shroom3^Gt(ROSA53)Sor/Shroom3^Gt(ROSA53)Sor	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA	MGI:7560662

Genotype
MGI:7531376

hm1

• Allelic Composition: Dvl2^tm1.2Wds/Dvl2^tm1.2Wds
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal heart development ( J:293794 )

• whole hearts from E12.5 embryos show a 60% reduction in Shroom3 expression; a global decrease in Shroom3 expression is seen throughout the heart, beginning at E10.5 and persisting through OFT formation and ventricular maturation at E11.5 and E12.5

Genotype
MGI:7560660

cx2

• Allelic Composition: Dvl2^tm1.2Wds/Dvl2⁺; Shroom3^{Gt(ROSA53)Sor}/Shroom3⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA

cardiovascular system

abnormal heart morphology ( J:293794 )

• at E14.5, one embryo shows planar cell polarity (PCP) associated cardiac defects, including DORV and membranous VSD

double outlet right ventricle ( J:293794 )

• at E14.5, one embryo shows DORV

perimembraneous ventricular septal defect ( J:293794 )

• at E14.5, one embryo shows a membranous VSD

Genotype
MGI:7560661

cx3

• Allelic Composition: Dvl2^tm1.2Wds/Dvl2^tm1.2Wds; Shroom3^{Gt(ROSA53)Sor}/Shroom3^{Gt(ROSA53)Sor}
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA

reproductive system

transmission ratio distortion ( J:293794 )

• when Shroom3^{Gt(ROSA53)Sor}/Shroom3⁺; Dvl2^tm1.2Wds/Dvl2⁺ are crossed to Shroom3^{Gt(ROSA53)Sor}/Shroom3⁺; Dvl2^tm1.2Wds/Dvl2^tm1.2Wds, no double knockout male mice are recovered at E14.5 (zero versus expected 4.75), indicating a gender bias due to Dvl2 loss

Genotype
MGI:7560662

cx4

• Allelic Composition: Dvl2^tm1.2Wds/Dvl2⁺; Shroom3^{Gt(ROSA53)Sor}/Shroom3^{Gt(ROSA53)Sor}
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA

reproductive system

transmission ratio distortion ( J:293794 )

• when Shroom3^{Gt(ROSA53)Sor}/Shroom3⁺; Dvl2^tm1.2Wds/Dvl2⁺ are crossed to Shroom3^{Gt(ROSA53)Sor}/Shroom3⁺; Dvl2^tm1.2Wds/Dvl2^tm1.2Wds, no male Shroom3^{Gt(ROSA53)Sor}Shroom3^{Gt(ROSA53)Sor};Dvl2^tm1.2Wds/Dvl2⁺ mice are recovered at E14.5