All Phenotypes Tsnaxip1<em1Osb> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tsnaxip1^em1Osb/Tsnaxip1^em1Osb	involves: C57BL/6J * DBA/2J	MGI:7531563
cx2	1700010I14Rik^em1Osb/1700010I14Rik^em1Osb Tsnaxip1^em1Osb/Tsnaxip1^em1Osb	involves: C57BL/6J * DBA/2J	MGI:7531572

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

decreased hyperactivated sperm motility ( J:340908 )

• spermatozoa exhibit low maximum bending angles of the midpiece in primary anti-hook curvature in capacitating medium, indicating impaired hyperactivation

decreased sperm progressive motility ( J:340908 )

• curvilinear velocity of spermatozoa at 10-min incubation is reduced

• percentage of progressively motile spermatozoa is reduced, likely due to their circular motion

• flagellar beating pattern of spermatozoa shows an asymmetric waveform

• however, mice do not exhibit a reduction in the percentage of motile spermatozoa and average path velocity and straight-line velocity are not different from wild-type

reduced male fertility ( J:340908 )

• males exhibit impaired fertility

• fertilization rates are reduced in in vitro fertilization using cumulus-intact oocytes but fertilization rates are rescued when the zonal pellucida is removed from oocytes

• however, no abnormalities are seen in gross morphology or weight of the testis or in spermatozoa

cellular

decreased hyperactivated sperm motility ( J:340908 )

• spermatozoa exhibit low maximum bending angles of the midpiece in primary anti-hook curvature in capacitating medium, indicating impaired hyperactivation

decreased sperm progressive motility ( J:340908 )

• percentage of progressively motile spermatozoa is reduced, likely due to their circular motion

• curvilinear velocity of spermatozoa at 10-min incubation is reduced

• flagellar beating pattern of spermatozoa shows an asymmetric waveform

• however, mice do not exhibit a reduction in the percentage of motile spermatozoa and average path velocity and straight-line velocity are not different from wild-type

Allelic Composition	1700010I14Rik^em1Osb/1700010I14Rik^em1Osb Tsnaxip1^em1Osb/Tsnaxip1^em1Osb
Genetic Background	involves: C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
1700010I14Rik^em1Osb mutation (2 available); any 1700010I14Rik mutation (37 available)
Tsnaxip1^em1Osb mutation (2 available); any Tsnaxip1 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

decreased hyperactivated sperm motility ( J:340908 )

• spermatozoa exhibit low maximum bending angles of the midpiece in primary anti-hook

• curvature in capacitating medium, indicating impaired hyperactivation

decreased sperm progressive motility ( J:340908 )

• spermatozoa exhibit impaired motility with circular travel paths

• flagellar beating pattern of spermatozoa shows an asymmetric waveform

reduced male fertility ( J:340908 )

• mice exhibit impaired fertility but are not infertile

• however, spermatozoa exhibit normal morphology

cellular

decreased hyperactivated sperm motility ( J:340908 )

• spermatozoa exhibit low maximum bending angles of the midpiece in primary anti-hook

• curvature in capacitating medium, indicating impaired hyperactivation

decreased sperm progressive motility ( J:340908 )

• spermatozoa exhibit impaired motility with circular travel paths

• flagellar beating pattern of spermatozoa shows an asymmetric waveform

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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