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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Chchd10em2Dpn
endonuclease-mediated mutation 2, Derek P Narendra
MGI:7532644
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Chchd10em2Dpn/Chchd10em2Dpn C57BL/6J-Chchd10em2Dpn MGI:7579312


Genotype
MGI:7579312
hm1
Allelic
Composition		 Chchd10em2Dpn/Chchd10em2Dpn
Genetic
Background		 C57BL/6J-Chchd10em2Dpn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chchd10em2Dpn mutation (0 available); any Chchd10 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
impaired coordination ( J:344465 )
• mice take longer to descend a 50 cm pole
• however, mice show normal rotarod performance at 25 weeks of age

cardiovascular system
abnormal heart morphology ( J:344465 )
• CHCHD10 protein aggregates are prominent in hearts; protein form filamentous aggregates that appear to be outside of mitochondria




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory