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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Zswim8em1Jtm
endonuclease-mediated mutation 1, Joshua T Mendell
MGI:7537043
Summary 3 genotypes


Genotype
MGI:7537162
hm1
Allelic
Composition		 Zswim8em1Jtm/Zswim8em1Jtm
Genetic
Background		 C57BL/6J-Zswim8em1Jtm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zswim8em1Jtm mutation (1 available); any Zswim8 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:338912 )
• die shortly after birth with none surviving to P1

respiratory system
abnormal lung development ( J:338912 )
• at E18.5 lungs appear less mature with less expanded saccule, thicker septa and minimally expanded terminal airspaces
small lung saccule ( J:338912 )
• less expanded at E18.5
respiratory failure ( J:338912 )
• agonal breathing at birth

cardiovascular system
ventricular septal defect ( J:338912 )
• in about 1/3 of embryos
globular heart ( J:338912 )
• globose in shape lacking a distinct apex
thin ventricular wall ( J:338912 )
• thinner and lacking compaction
dilated heart ventricle ( J:338912 )
• dilated ventricles

growth/size/body
decreased birth weight ( J:338912 )
• over a 20% reduction in body weight at E18.5




Genotype
MGI:7537173
cx2
Allelic
Composition		 Mirc24em1Jtm/Mirc24em1Jtm
Zswim8em1Jtm/Zswim8em1Jtm
Genetic
Background		 C57BL/6J-Zswim8em1Jtm Mirc24em1Jtm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc24em1Jtm mutation (1 available); any Mirc24 mutation (3 available)
Zswim8em1Jtm mutation (1 available); any Zswim8 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:338912 )
• die shortly after birth

respiratory system
abnormal lung development ( J:338912 )
• neonates have immature lungs at the late canalicular stage

cardiovascular system
globular heart ( J:338912 )
• globose in shape lacking a distinct apex

growth/size/body
growth/size/body region phenotype ( J:338912 )
• loss of expression of Mir322 and Mir503 rescues the prenatal growth defect




Genotype
MGI:7537174
cx3
Allelic
Composition		 Mirc24em1Jtm/Y
Zswim8em1Jtm/Zswim8em1Jtm
Genetic
Background		 C57BL/6J-Zswim8em1Jtm Mirc24em1Jtm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc24em1Jtm mutation (1 available); any Mirc24 mutation (3 available)
Zswim8em1Jtm mutation (1 available); any Zswim8 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:338912 )
• die shortly after birth

respiratory system
abnormal lung development ( J:338912 )
• neonates have immature lungs at the late canalicular stage

cardiovascular system
globular heart ( J:338912 )
• globose in shape lacking a distinct apex

growth/size/body
growth/size/body region phenotype ( J:338912 )
N
• loss of expression of Mir322 and Mir503 rescues the prenatal growth defect




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory