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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Zswim8em2Jtm
endonuclease-mediated mutation 2, Joshua T Mendell
MGI:7537044
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Zswim8em2Jtm/Zswim8em2Jtm
Tg(Nkx2-5-cre)9Eno/0 		involves: C57BL/6J MGI:7537170


Genotype
MGI:7537170
cn1
Allelic
Composition		 Zswim8em2Jtm/Zswim8em2Jtm
Tg(Nkx2-5-cre)9Eno/0
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Nkx2-5-cre)9Eno mutation (0 available)
Zswim8em2Jtm mutation (1 available); any Zswim8 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:338912 )
N
• unlike germline null mice, conditional loss in hear progenitor cells does not result i neonatal lethality

cardiovascular system
globular heart ( J:338912 )
• apex is less distinct
• cardiac phenotypes are less severe than in germline null mice
dilated heart ventricle ( J:338912 )
• dilated ventricles




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory