Phenotypes associated with this allele

• Allele Symbol: Tars3^em1Smoc
• Allele Name: endonuclease-mediated mutation 1, Shanghai Model Organisms
• Allele ID: MGI:7539368
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tars3^em1Smoc/Tars3^em1Smoc	C57BL/6-Tars3^em1Smoc	MGI:7541146

Genotype
MGI:7541146

hm1

• Allelic Composition: Tars3^em1Smoc/Tars3^em1Smoc
• Genetic Background: C57BL/6-Tars3^em1Smoc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased lean body mass ( J:341137 )

• mice are leaner than wild-type mice

postnatal growth retardation ( J:341137 )

• mice show normal weight at 3 days after birth, however by 3 weeks of age, decreased weight is obvious and mice exhibit a progressive decrease in size after birth

homeostasis/metabolism

decreased circulating glucose level ( J:341137 )

decreased fasting circulating glucose level ( J:341137 )

decreased circulating cholesterol level ( J:341137 )

decreased circulating HDL cholesterol level ( J:341137 )

decreased circulating LDL cholesterol level ( J:341137 )

decreased circulating triglyceride level ( J:341137 )

improved glucose tolerance ( J:341137 )

• blood glucose levels in 6-week-old mice after 5 hours of starvation are decreased as determined by glucose tolerance test

increased insulin sensitivity ( J:341137 )

• blood glucose levels in 6-week-old mice after 5 hours of starvation as detected by insulin tolerance test are decreased

limbs/digits/tail

abnormal soleus morphology ( J:341137 )

• size of the soleus muscle is smaller

abnormal tibialis anterior morphology ( J:341137 )

• size of the tibialis anterior muscle is smaller

muscle

abnormal soleus morphology ( J:341137 )

• size of the soleus muscle is smaller

abnormal tibialis anterior morphology ( J:341137 )

• size of the tibialis anterior muscle is smaller

decreased skeletal muscle fiber size ( J:341137 )

• muscle fiber size in both the tibialis anterior and soleus muscle are smaller

skeleton

increased bone trabecula number ( J:341137 )

abnormal bone trabecular spacing ( J:341137 )

• trabecular separation of cancellous bone is decreased

• however, no difference in trabecular thickness, bone mineral density, or cortical bone thickness is seen

increased bone mass ( J:341137 )

• 8-week-old bones exhibit increased bone mass per tissue volume

abnormal skeleton development ( J:341137 )

• 8-week-old mice exhibit ossified and clear bone trabeculae in the distal femur that is not seen in wild-type mice at this time, indicating abnormal bone development