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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Iqchem2Alfon
endonuclease-mediated mutation 2, Alfonso Gutierrez-Adan
MGI:7539523
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Iqchem2Alfon/Iqchem2Alfon involves: C57BL/6 * CBA MGI:7619846


Genotype
MGI:7619846
hm1
Allelic
Composition		 Iqchem2Alfon/Iqchem2Alfon
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Iqchem2Alfon mutation (0 available); any Iqch mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
oligozoospermia ( J:338977 )
• sperm concentration is decreased
• mice show a reduction in only the population of haploid cells (round and/or elongated spermatids) and not in 2n and 4n germ cells
teratozoospermia ( J:338977 )
• over 80% of sperm show morphological abnormalities in the neck, midpiece, head and tail
abnormal acrosome morphology ( J:338977 )
• spermatids exhibit fewer acrosomal structures and acrosomal cap structures that are discontinuous, abnormally fragmented and with malformations
abnormal seminiferous tubule morphology ( J:338977 )
• testes show some near-empty seminiferous tubules, disorganized tubules with abnormal spermatids and few spermatozoa
abnormal sperm physiology ( J:338977 )
• sperm show reduced viability
asthenozoospermia ( J:338977 )
• sperm show reduced motility

endocrine/exocrine glands
abnormal seminiferous tubule morphology ( J:338977 )
• testes show some near-empty seminiferous tubules, disorganized tubules with abnormal spermatids and few spermatozoa

cellular
oligozoospermia ( J:338977 )
• sperm concentration is decreased
• mice show a reduction in only the population of haploid cells (round and/or elongated spermatids) and not in 2n and 4n germ cells
teratozoospermia ( J:338977 )
• over 80% of sperm show morphological abnormalities in the neck, midpiece, head and tail
abnormal acrosome morphology ( J:338977 )
• spermatids exhibit fewer acrosomal structures and acrosomal cap structures that are discontinuous, abnormally fragmented and with malformations
asthenozoospermia ( J:338977 )
• sperm show reduced motility




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory