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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Taok1em1Cya
endonuclease-mediated mutation 1, Cyagen Biosciences
MGI:7539703
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Taok1em1Cya/Taok1em1Cya C57BL/6J-Taok1em1Cya MGI:7627166
cn2
 		Taok1em1Cya/Taok1em1Cya
Tg(Slc17a8-icre)1Edw/0 		involves: C57BL/6J * FVB/N MGI:7627167


Genotype
MGI:7627166
cn1
Allelic
Composition		 Taok1em1Cya/Taok1em1Cya
Genetic
Background		 C57BL/6J-Taok1em1Cya
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Taok1em1Cya mutation (0 available); any Taok1 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
increased grooming behavior ( J:341142 )
• mice injected with an adeno-associated virus expressing cre recombinase into the dorsal raphe nucleus exhibit increased grooming time
increased stereotypic behavior ( J:341142 )
• mice injected with an adeno-associated virus expressing cre recombinase into the dorsal raphe nucleus exhibit increased marble burying
decreased social investigation ( J:341142 )
• mice injected with an adeno-associated virus expressing cre recombinase (AAV-hSyn-Cre-GFP) into the dorsal raphe nucleus exhibit impaired sociability in the intruder test




Genotype
MGI:7627167
cn2
Allelic
Composition		 Taok1em1Cya/Taok1em1Cya
Tg(Slc17a8-icre)1Edw/0
Genetic
Background		 involves: C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Taok1em1Cya mutation (0 available); any Taok1 mutation (45 available)
Tg(Slc17a8-icre)1Edw mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
increased stereotypic behavior ( J:341142 )
• mice exhibit increased marble burying
decreased social investigation ( J:341142 )
• mice exhibit decreased social interaction time in the intruder test




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory