Analysis Tools
reproductive system
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• females are infertile, even after 5 months of mating
• however, oocytes produced by females show no morphological abnormalities and females ovulate normal numbers of eggs which can be fertilized both in vitro and in vivo
• however, males exhibit normal fertility and testis morphology
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cellular
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• although eggs from homozygous females are able to be fertilized by wild-type males, none progress beyond the two-cell stage to blastocyst when cultured in vitro and the two-cell arrest occurs in vivo
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