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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tnni3kB
B
MGI:7539710
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tnni3kB/Tnni3kB involves: C57BL/6J * DBA/2J MGI:7540879
cx2
 		Tg(Myh6-CASQ2)1Mord/0
Tnni3kB/Tnni3kA 		involves: AKR/J * DBA/2J MGI:7540821
cx3
 		Tg(Myh6-CASQ2)1Mord/0
Tnni3kB/Tnni3kB 		involves: AKR/J * DBA/2J MGI:7540830
cx4
 		Tg(Myh6-CASQ2)1Mord/0
Tg(Myh6-TNNI3K)#Dmar/0
Tnni3kB/Tnni3kB 		involves: C57BL/6J * DBA/2J * SJL/J MGI:7540832
cx5
 		Tg(Myh6-TNNI3K)#Dmar/0
Tnni3kB/Tnni3kB 		involves: C57BL/6J * DBA/2J * SJL/J MGI:7540837


Genotype
MGI:7540879
hm1
Allelic
Composition		 Tnni3kB/Tnni3kB
Genetic
Background		 involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnni3kB mutation (0 available); any Tnni3k mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased heart left ventricle posterior wall thickness ( J:339644 )
• reduced left ventricular posterior wall thickness at end-diastole (LVPW)
decreased cardiac muscle contractility ( J:339644 )
• reduced fractional shortening

homeostasis/metabolism
insulin resistance ( J:339644 )
• reduced insulin response after oral glucose administration

muscle
decreased cardiac muscle contractility ( J:339644 )
• reduced fractional shortening




Genotype
MGI:7540821
cx2
Allelic
Composition		 Tg(Myh6-CASQ2)1Mord/0
Tnni3kB/Tnni3kA
Genetic
Background		 involves: AKR/J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6-CASQ2)1Mord mutation (0 available)
Tnni3kA mutation (0 available); any Tnni3k mutation (47 available)
Tnni3kB mutation (0 available); any Tnni3k mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased cardiac muscle contractility ( J:154116 )
• reduced fractional shortening at age 4 and 8 weeks

mortality/aging
extended life span ( J:154116 )
• average 107-day survival (vs 40 days for homozygous Tnni3k (WT) with transgene)

muscle
decreased cardiac muscle contractility ( J:154116 )
• reduced fractional shortening at age 4 and 8 weeks




Genotype
MGI:7540830
cx3
Allelic
Composition		 Tg(Myh6-CASQ2)1Mord/0
Tnni3kB/Tnni3kB
Genetic
Background		 involves: AKR/J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6-CASQ2)1Mord mutation (0 available)
Tnni3kB mutation (0 available); any Tnni3k mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
extended life span ( J:154116 )
• average 150-day survival (vs 40 days for homozygous Tnni3k (WT) with transgene)




Genotype
MGI:7540832
cx4
Allelic
Composition		 Tg(Myh6-CASQ2)1Mord/0
Tg(Myh6-TNNI3K)#Dmar/0
Tnni3kB/Tnni3kB
Genetic
Background		 involves: C57BL/6J * DBA/2J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6-CASQ2)1Mord mutation (0 available)
Tg(Myh6-TNNI3K)#Dmar mutation (0 available)
Tnni3kB mutation (0 available); any Tnni3k mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
dilated cardiomyopathy ( J:154116 )
• at around age 14 days
decreased cardiac muscle contractility ( J:154116 )
• reduced fractional shortening at around age 14 days
decreased heart rate ( J:154116 )
• at around age 14 days

mortality/aging
premature death ( J:154116 )
• average 21-day survival (vs 40 days for homozygous Tnni3k (WT) with CASQ2 transgene only)

muscle
dilated cardiomyopathy ( J:154116 )
• at around age 14 days
decreased cardiac muscle contractility ( J:154116 )
• reduced fractional shortening at around age 14 days




Genotype
MGI:7540837
cx5
Allelic
Composition		 Tg(Myh6-TNNI3K)#Dmar/0
Tnni3kB/Tnni3kB
Genetic
Background		 involves: C57BL/6J * DBA/2J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6-TNNI3K)#Dmar mutation (0 available)
Tnni3kB mutation (0 available); any Tnni3k mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
increased response of heart to induced stress ( J:154116 )
• increased left-ventricular end diastolic diameter (LVEDD) and left-ventricular end systolic diameter (LVESD) after transverse aortic constriction (TAC)
• reduced fractional shortening at age 4 and 8 weeks after TAC

homeostasis/metabolism
increased response of heart to induced stress ( J:154116 )
• increased left-ventricular end diastolic diameter (LVEDD) and left-ventricular end systolic diameter (LVESD) after transverse aortic constriction (TAC)
• reduced fractional shortening at age 4 and 8 weeks after TAC




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory