About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tnni3kB
B
MGI:7539710
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tnni3kB/Tnni3kB involves: C57BL/6J * DBA/2J MGI:7540879
cx2
 		Tg(Myh6-CASQ2)1Mord/0
Tnni3kB/Tnni3kA 		involves: AKR/J * DBA/2J MGI:7540821
cx3
 		Tg(Myh6-CASQ2)1Mord/0
Tnni3kB/Tnni3kB 		involves: AKR/J * DBA/2J MGI:7540830
cx4
 		Tg(Myh6-CASQ2)1Mord/0
Tg(Myh6-TNNI3K)#Dmar/0
Tnni3kB/Tnni3kB 		involves: C57BL/6J * DBA/2J * SJL/J MGI:7540832
cx5
 		Tg(Myh6-TNNI3K)#Dmar/0
Tnni3kB/Tnni3kB 		involves: C57BL/6J * DBA/2J * SJL/J MGI:7540837


Genotype
MGI:7540879
hm1
Allelic
Composition		 Tnni3kB/Tnni3kB
Genetic
Background		 involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnni3kB mutation (0 available); any Tnni3k mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased heart left ventricle posterior wall thickness ( J:339644 )
• reduced left ventricular posterior wall thickness at end-diastole (LVPW)
decreased cardiac muscle contractility ( J:339644 )
• reduced fractional shortening

homeostasis/metabolism
insulin resistance ( J:339644 )
• reduced insulin response after oral glucose administration

muscle
decreased cardiac muscle contractility ( J:339644 )
• reduced fractional shortening




Genotype
MGI:7540821
cx2
Allelic
Composition		 Tg(Myh6-CASQ2)1Mord/0
Tnni3kB/Tnni3kA
Genetic
Background		 involves: AKR/J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6-CASQ2)1Mord mutation (0 available)
Tnni3kA mutation (0 available); any Tnni3k mutation (47 available)
Tnni3kB mutation (0 available); any Tnni3k mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased cardiac muscle contractility ( J:154116 )
• reduced fractional shortening at age 4 and 8 weeks

mortality/aging
extended life span ( J:154116 )
• average 107-day survival (vs 40 days for homozygous Tnni3k (WT) with transgene)

muscle
decreased cardiac muscle contractility ( J:154116 )
• reduced fractional shortening at age 4 and 8 weeks




Genotype
MGI:7540830
cx3
Allelic
Composition		 Tg(Myh6-CASQ2)1Mord/0
Tnni3kB/Tnni3kB
Genetic
Background		 involves: AKR/J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6-CASQ2)1Mord mutation (0 available)
Tnni3kB mutation (0 available); any Tnni3k mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
extended life span ( J:154116 )
• average 150-day survival (vs 40 days for homozygous Tnni3k (WT) with transgene)




Genotype
MGI:7540832
cx4
Allelic
Composition		 Tg(Myh6-CASQ2)1Mord/0
Tg(Myh6-TNNI3K)#Dmar/0
Tnni3kB/Tnni3kB
Genetic
Background		 involves: C57BL/6J * DBA/2J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6-CASQ2)1Mord mutation (0 available)
Tg(Myh6-TNNI3K)#Dmar mutation (0 available)
Tnni3kB mutation (0 available); any Tnni3k mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
dilated cardiomyopathy ( J:154116 )
• at around age 14 days
decreased cardiac muscle contractility ( J:154116 )
• reduced fractional shortening at around age 14 days
decreased heart rate ( J:154116 )
• at around age 14 days

mortality/aging
premature death ( J:154116 )
• average 21-day survival (vs 40 days for homozygous Tnni3k (WT) with CASQ2 transgene only)

muscle
dilated cardiomyopathy ( J:154116 )
• at around age 14 days
decreased cardiac muscle contractility ( J:154116 )
• reduced fractional shortening at around age 14 days




Genotype
MGI:7540837
cx5
Allelic
Composition		 Tg(Myh6-TNNI3K)#Dmar/0
Tnni3kB/Tnni3kB
Genetic
Background		 involves: C57BL/6J * DBA/2J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6-TNNI3K)#Dmar mutation (0 available)
Tnni3kB mutation (0 available); any Tnni3k mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
increased response of heart to induced stress ( J:154116 )
• increased left-ventricular end diastolic diameter (LVEDD) and left-ventricular end systolic diameter (LVESD) after transverse aortic constriction (TAC)
• reduced fractional shortening at age 4 and 8 weeks after TAC

homeostasis/metabolism
increased response of heart to induced stress ( J:154116 )
• increased left-ventricular end diastolic diameter (LVEDD) and left-ventricular end systolic diameter (LVESD) after transverse aortic constriction (TAC)
• reduced fractional shortening at age 4 and 8 weeks after TAC




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory