Phenotypes associated with this allele

• Allele Symbol: U90926^em1Dnkv
• Allele Name: endonuclease-mediated mutation 1, Dimitry Krementsov
• Allele ID: MGI:7541071
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	U90926^em1Dnkv/U90926^em1Dnkv	C57BL6/J-U90926^em1Dnkv	MGI:7541190

Genotype
MGI:7541190

hm1

• Allelic Composition: U90926^em1Dnkv/U90926^em1Dnkv
• Genetic Background: C57BL6/J-U90926^em1Dnkv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:340649 )

• mice treated with LPS exhibit increased sickness and reduced survival compared with wild-type mice

immune system

increased circulating interleukin-6 level ( J:340649 )

• levels remain elevated after 24 h in mice treated with LPS

increased susceptibility to endotoxin shock ( J:340649 )

• mice treated with LPS exhibit increased sickness and reduced survival compared with wild-type mice

• however, neutralization of IL6 improves endotoxemia outcome

increased susceptibility to bacterial infection induced morbidity/mortality ( J:340649 )

• mice treated with LPS exhibit increased sickness and reduced survival compared with wild-type mice

homeostasis/metabolism

increased circulating interleukin-6 level ( J:340649 )

• levels remain elevated after 24 h in mice treated with LPS