Phenotypes associated with this allele

• Allele Symbol: Glipr1l1^em1Mkob
• Allele Name: endonuclease-mediated mutation 1, Moira K O'Bryan
• Allele ID: MGI:7541080
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Glipr1l1^em1Mkob/Glipr1l1^em1Mkob	Not Specified	MGI:7545596

Genotype
MGI:7545596

hm1

• Allelic Composition: Glipr1l1^em1Mkob/Glipr1l1^em1Mkob
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

impaired acrosome reaction ( J:290694 )

♂ • sperm exhibit a reduced ability to undergo the progesterone-induced acrosome reaction , with only about 17% of spermatozoa retaining the ability to undergo an acrosome reaction compared to 54% of wild-type spermatozoa

abnormal sperm-egg fusion ( J:290694 )

♂ • sperm are able to bind the zona pellucida but have reduced ability to fertilize oocytes in vitro, indicating impaired sperm-oocyte fusion

♂ • however, males sire litters of equivalent size to that of controls, indicating normal fertility and males show normal testicular histology, no differences in body weight, testis weight, or daily sperm production, normal sperm motility (total and progressive motility and sperm velocity), and normal sperm capacitation