Phenotypes associated with this allele

• Allele Symbol: Slc39a8^tm1.1Brvo
• Allele Name: targeted mutation 1.1, Bruno Vogt
• Allele ID: MGI:7541328
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc39a8^tm1.1Brvo/Slc39a8^tm1.1Brvo	involves: C57BL/6	MGI:7541359

Genotype
MGI:7541359

hm1

• Allelic Composition: Slc39a8^tm1.1Brvo/Slc39a8^tm1.1Brvo
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:341571 )

N • normal heartrate

hypotension ( J:341571 )

endocrine/exocrine glands

increased insulin secretion ( J:341571 )

• after intraperitoneal glucose injection after fasting and on high-sugar diet

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:341571 )

N • normal HDL-C and LDL-C levels

abnormal homeostasis ( J:341571 )

• reduced palladium levels in plasma and liver

• reduced mercury and undetectable lithium levels in liver

• reduced cobalt and doubled platinum levels in kidney

• normal manganese, zinc and iron levels in plasma, liver and kidney

increased insulin secretion ( J:341571 )

• after intraperitoneal glucose injection after fasting and on high-sugar diet

decreased circulating glucose level ( J:341571 )

• glucose levels dont rise after fasting and on high-sugar diet

• reduced rise in glucose levels after intraperitoneal glucose injection after fasting and on high-sugar diet

increased circulating glucose level ( J:341571 )

• glucose levels remain high after intraperitoneal glucose followed by insulin injection after fasting and on standard diet or high-sugar diet

• normal after intraperitoneal glucose injection after fasting and on standard diet

increased circulating insulin level ( J:341571 )

• after fasting and on standard diet

• after intraperitoneal glucose injection after fasting and on high-sugar diet

increased circulating phosphate level ( J:341571 )

increased urine glucose level ( J:341571 )

insulin resistance ( J:341571 )

• after intraperitoneal glucose followed by insulin injection after fasting and on standard diet or high-sugar diet

renal/urinary system

increased urine glucose level ( J:341571 )

skeleton

skeleton phenotype ( J:341571 )

N • normal bone structure