Phenotypes associated with this allele

• Allele Symbol: Pgc^em1Hcz
• Allele Name: endonuclease-mediated mutation 1, Hua-Chuan Zheng
• Allele ID: MGI:7543060
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pgc^em1Hcz/Pgc^em1Hcz	Not Specified	MGI:7543154

Genotype
MGI:7543154

hm1

• Allelic Composition: Pgc^em1Hcz/Pgc^em1Hcz
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:338079 )

• mice exhibit reduced survival compared to wild-type mice

hematopoietic system

decreased erythrocyte cell number ( J:338079 )

decreased hemoglobin content ( J:338079 )

neoplasm

decreased incidence of tumors by chemical induction ( J:338079 )

• mild to moderate adenocarcinoma in the stomach of MNU-treated mice compared with similarly treated wild-type mice

digestive/alimentary system

abnormal stomach glandular epithelium morphology ( J:338079 )

• regenerative and globoid dysplasia in untreated and MNU-treated mice

homeostasis/metabolism

decreased circulating alkaline phosphatase level ( J:338079 )

decreased incidence of tumors by chemical induction ( J:338079 )

• mild to moderate adenocarcinoma in the stomach of MNU-treated mice compared with similarly treated wild-type mice