All Phenotypes Mib1<em1Jlp> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Mib1^em1Jlp/Mib1^tm2Kong Tg(Tnnt2-cre)5Blh/0	involves: 129P2/OlaHsd * C57BL/6 * DBA/2	MGI:7544909
cx2	Apcdd1^em1Jlp/Apcdd1⁺ Asxl3^em1Jlp/Asxl3⁺ Mib1^em1Jlp/Mib1⁺	C57BL/6-Apcdd1^em1Jlp Asxl3^em1Jlp Mib1^em1Jlp	MGI:7544919
cx3	Mib1^em1Jlp/Mib1⁺ Notch1^tm1Con/Notch1⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:7544913

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal trabecula carnea morphology ( J:338889 )

• noncompacted trabeculae in ventricular myocardium in adults

thin left ventricle myocardium compact layer ( J:338889 )

• left ventricular compact layer 45% thinner in E16.5 embryos

• reduced compact-to-trabecular myocardium ratio in E16.5 embryos

abnormal cardiac outflow tract development ( J:338889 )

• various conotruncal defects in E16.5 embryos

abnormal aortic valve morphology ( J:338889 )

• dysplasia in adults

bicuspid aortic valve ( J:338889 )

• in E16.5 embryos

dilated heart ventricle ( J:338889 )

• in adults

cardiac fibrosis ( J:338889 )

• myocardial fibrosis in septum and around coronary vessels in adults

decreased cardiac muscle contractility ( J:338889 )

• reduced fractional shortening and ejection fraction in adults

aortic valve regurgitation ( J:338889 )

• in adults

mortality/aging

lethality during fetal growth through weaning, incomplete penetrance ( J:338889 )

• only 5% of embryos develop to adulthood

muscle

abnormal trabecula carnea morphology ( J:338889 )

• noncompacted trabeculae in ventricular myocardium in adults

thin left ventricle myocardium compact layer ( J:338889 )

• left ventricular compact layer 45% thinner in E16.5 embryos

• reduced compact-to-trabecular myocardium ratio in E16.5 embryos

decreased cardiac muscle contractility ( J:338889 )

• reduced fractional shortening and ejection fraction in adults

Allelic Composition	Apcdd1^em1Jlp/Apcdd1⁺ Asxl3^em1Jlp/Asxl3⁺ Mib1^em1Jlp/Mib1⁺
Genetic Background	C57BL/6-Apcdd1^em1Jlp Asxl3^em1Jlp Mib1^em1Jlp

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apcdd1^em1Jlp mutation (0 available); any Apcdd1 mutation (50 available)
Asxl3^em1Jlp mutation (0 available); any Asxl3 mutation (99 available)
Mib1^em1Jlp mutation (0 available); any Mib1 mutation (55 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

thin ventricle myocardium compact layer ( J:338889 )

• in E16.5 embryos

• reduced compact-to-trabecular myocardium ratio in E16.5 embryos

increased heart left ventricle weight ( J:338889 )

• in adults

dilated heart ( J:338889 )

• dilated atria and ventricles in adults

increased cardiac output ( J:338889 )

• elevated systolic and end diastolic volume in adults

muscle

thin ventricle myocardium compact layer ( J:338889 )

• in E16.5 embryos

• reduced compact-to-trabecular myocardium ratio in E16.5 embryos

Allelic Composition	Mib1^em1Jlp/Mib1⁺ Notch1^tm1Con/Notch1⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mib1^em1Jlp mutation (0 available); any Mib1 mutation (55 available)
Notch1^tm1Con mutation (3 available); any Notch1 mutation (117 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:338889 )

N	• normal valve morphology in E16.5 embryos

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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