Phenotypes associated with this allele

• Allele Symbol: Mcemp1^em1Jngj
• Allele Name: endonuclease-mediated mutation 1, Jae U Jung
• Allele ID: MGI:7543594
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mcemp1^em1Jngj/Mcemp1^em1Jngj	C57BL/6-Mcemp1^em1Jngj	MGI:7543600

Genotype
MGI:7543600

hm1

• Allelic Composition: Mcemp1^em1Jngj/Mcemp1^em1Jngj
• Genetic Background: C57BL/6-Mcemp1^em1Jngj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal mast cell differentiation ( J:335318 )

• reduced expansion of peritoneal cells cultured with SCF and IL3

• reduced lung mast cell proliferation in mice subjected to intranasally challenged SCF

• however, expansion of bone marrow cells cultured with SCF and IL3 exhibit normal expansion

abnormal type I hypersensitivity reaction ( J:335318 )

• reduced airway inflammation, fibrosis, and collagen deposition in the lungs of an ovalbumin-induced chronic asthma model

hematopoietic system

abnormal mast cell differentiation ( J:335318 )

• reduced expansion of peritoneal cells cultured with SCF and IL3

• reduced lung mast cell proliferation in mice subjected to intranasally challenged SCF

• however, expansion of bone marrow cells cultured with SCF and IL3 exhibit normal expansion

cellular

abnormal mast cell differentiation ( J:335318 )

• reduced expansion of peritoneal cells cultured with SCF and IL3

• reduced lung mast cell proliferation in mice subjected to intranasally challenged SCF

• however, expansion of bone marrow cells cultured with SCF and IL3 exhibit normal expansion