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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Elmo2tm1c(EUCOMM)Hmgu
targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
MGI:7544981
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Elmo2tm1c(EUCOMM)Hmgu/Elmo2tm1c(EUCOMM)Hmgu
Pax3tm1(cre)Joe/Pax3+ 		involves: 129 * C57BL/6N MGI:7545143
cn2
 		Elmo1tm1.2Ravi/Elmo1tm1.2Ravi
Elmo2tm1c(EUCOMM)Hmgu/Elmo2tm1c(EUCOMM)Hmgu
Myf5tm3(cre)Sor/Myf5+ 		involves: 129P2/OlaHsd * C57BL/6N MGI:7545138
cn3
 		Elmo1tm1.2Ravi/Elmo1tm1.2Ravi
Elmo2tm1c(EUCOMM)Hmgu/Elmo2tm1c(EUCOMM)Hmgu
Pax3tm1(cre)Joe/Pax3+ 		involves: 129P2/OlaHsd * C57BL/6N MGI:7545139
cn4
 		Elmo2tm1c(EUCOMM)Hmgu/Elmo2tm1c(EUCOMM)Hmgu
Meox2tm1(cre)Sor/Meox2+ 		involves: 129S4/SvJaeSor * C57BL/6N MGI:7545141
cn5
 		Elmo2tm1c(EUCOMM)Hmgu/Elmo2tm1c(EUCOMM)Hmgu
Myf5tm3(cre)Sor/Myf5+ 		involves: 129S4/SvJaeSor * C57BL/6N MGI:7545142


Genotype
MGI:7545143
cn1
Allelic
Composition		 Elmo2tm1c(EUCOMM)Hmgu/Elmo2tm1c(EUCOMM)Hmgu
Pax3tm1(cre)Joe/Pax3+
Genetic
Background		 involves: 129 * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elmo2tm1c(EUCOMM)Hmgu mutation (0 available); any Elmo2 mutation (37 available)
Pax3tm1(cre)Joe mutation (1 available); any Pax3 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, incomplete penetrance ( J:331473 )
• fewer than expected mice are present at weaning




Genotype
MGI:7545138
cn2
Allelic
Composition		 Elmo1tm1.2Ravi/Elmo1tm1.2Ravi
Elmo2tm1c(EUCOMM)Hmgu/Elmo2tm1c(EUCOMM)Hmgu
Myf5tm3(cre)Sor/Myf5+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elmo1tm1.2Ravi mutation (0 available); any Elmo1 mutation (59 available)
Elmo2tm1c(EUCOMM)Hmgu mutation (0 available); any Elmo2 mutation (37 available)
Myf5tm3(cre)Sor mutation (1 available); any Myf5 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality during fetal growth through weaning, complete penetrance ( J:331473 )
• no mice are present after weaning
• however, higher than Mendelian ratios at E14.5

muscle
abnormal muscle development ( J:331473 )
• only mononucleated muscle cells at E14.5
• reduced muscle content at E16.5




Genotype
MGI:7545139
cn3
Allelic
Composition		 Elmo1tm1.2Ravi/Elmo1tm1.2Ravi
Elmo2tm1c(EUCOMM)Hmgu/Elmo2tm1c(EUCOMM)Hmgu
Pax3tm1(cre)Joe/Pax3+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elmo1tm1.2Ravi mutation (0 available); any Elmo1 mutation (59 available)
Elmo2tm1c(EUCOMM)Hmgu mutation (0 available); any Elmo2 mutation (37 available)
Pax3tm1(cre)Joe mutation (1 available); any Pax3 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality during fetal growth through weaning, complete penetrance ( J:331473 )
• no mice are present after weaning
• however, normal Mendelian ratios at E14.5

muscle
abnormal muscle development ( J:331473 )
• only mononucleated muscle cells at E14.5
• reduced muscle content at E16.5
abnormal diaphragm development ( J:331473 )
• smaller thickness at E16.5 with a failure to attach to the ribs




Genotype
MGI:7545141
cn4
Allelic
Composition		 Elmo2tm1c(EUCOMM)Hmgu/Elmo2tm1c(EUCOMM)Hmgu
Meox2tm1(cre)Sor/Meox2+
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elmo2tm1c(EUCOMM)Hmgu mutation (0 available); any Elmo2 mutation (37 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, complete penetrance ( J:331473 )
• no mice are present at weaning




Genotype
MGI:7545142
cn5
Allelic
Composition		 Elmo2tm1c(EUCOMM)Hmgu/Elmo2tm1c(EUCOMM)Hmgu
Myf5tm3(cre)Sor/Myf5+
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elmo2tm1c(EUCOMM)Hmgu mutation (0 available); any Elmo2 mutation (37 available)
Myf5tm3(cre)Sor mutation (1 available); any Myf5 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, incomplete penetrance ( J:331473 )
• fewer than expected mice are present at weaning




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory