Phenotypes associated with this allele

• Allele Symbol: Elmo2^tm1.1Jfco
• Allele Name: targeted mutation 1.1, Jean-Francois Cote
• Allele ID: MGI:7544996
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Elmo2^tm1.1Jfco/Elmo2^tm1.1Jfco	involves: 129 * C57BL/6	MGI:7545144
cx2	Elmo1^tm1.2Ravi/Elmo1^tm1.2Ravi Elmo2^tm1.1Jfco/Elmo2^tm1.1Jfco	involves: 129P2/OlaHsd * C57BL/6	MGI:7545145

Genotype
MGI:7545144

hm1

• Allelic Composition: Elmo2^tm1.1Jfco/Elmo2^tm1.1Jfco
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:331473 )

• mice are viable with no gross abnormalities with normal muscle morphology and regeneration

Genotype
MGI:7545145

cx2

• Allelic Composition: Elmo1^tm1.2Ravi/Elmo1^tm1.2Ravi; Elmo2^tm1.1Jfco/Elmo2^tm1.1Jfco
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

mortality/aging

preweaning lethality, incomplete penetrance ( J:331473 )

• fewer than expected mice are present at weaning

muscle

abnormal muscle development ( J:331473 )

• reduced number of nuclei per myofiber indicating less fusion

decreased skeletal muscle fiber size ( J:331473 )

impaired skeletal muscle regeneration ( J:331473 )

• following cardiotoxin-induced injury