All Phenotypes Elmo2<tm2.1Jfco> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Elmo2^tm2.1Jfco
targeted mutation 2.1, Jean-Francois Cote
MGI:7544997

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Elmo2^tm2.1Jfco/Elmo2^tm2.1Jfco	involves: 129 * C57BL/6	MGI:7545146
cx2	Dysf^prmd/Dysf^prmd Elmo2^tm2.1Jfco/Elmo2^tm2.1Jfco	involves: 129 * A/J * C57BL/6	MGI:7545148
cx3	Elmo1^tm1.2Ravi/Elmo1^tm1.2Ravi Elmo2^tm2.1Jfco/Elmo2^tm2.1Jfco	involves: 129P2/OlaHsd * C57BL/6	MGI:7545147

Allelic Composition	Elmo2^tm2.1Jfco/Elmo2^tm2.1Jfco
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elmo2^tm2.1Jfco mutation (0 available); any Elmo2 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

increased skeletal muscle fiber size ( J:331473 )

• with increased nuclei per fiber

enhanced skeletal muscle regeneration ( J:331473 )

• following cardiotoxin (CTX)-induced injury

• however, fiber size and nuclei number per fiber is like wild-type 7 days after CTX-induced injury

Allelic Composition	Dysf^prmd/Dysf^prmd Elmo2^tm2.1Jfco/Elmo2^tm2.1Jfco
Genetic Background	involves: 129 * A/J * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dysf^prmd mutation (6 available); any Dysf mutation (184 available)
Elmo2^tm2.1Jfco mutation (0 available); any Elmo2 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

muscle phenotype ( J:331473 )

N	• mice exhibit restored muscle regeneration following cardiotoxin-induced injury compared with Dysf^prmd homozygotes

Allelic Composition	Elmo1^tm1.2Ravi/Elmo1^tm1.2Ravi Elmo2^tm2.1Jfco/Elmo2^tm2.1Jfco
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elmo1^tm1.2Ravi mutation (0 available); any Elmo1 mutation (59 available)
Elmo2^tm2.1Jfco mutation (0 available); any Elmo2 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality during fetal growth through weaning, complete penetrance ( J:331473 )

• no mice are present after weaning

embryonic lethality, incomplete penetrance ( J:331473 )

• fewer than expected mice are present at E14.5

embryo

abnormal embryo development ( J:331473 )

• at E14.5 and E16.5

• however, muscle development is normal

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24