Phenotypes associated with this allele

• Allele Symbol: Elac2^em1Afi
• Allele Name: endonuclease-mediated mutation 1, Aleksandra Filipovska
• Allele ID: MGI:7545038
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Elac2^em1Afi/Elac2^em1Afi	C57BL/6N-Elac2^em1Afi	MGI:7545183
cx2	Elac2^em1Afi/Elac2^em1Afi Tg(TRAMP)8247Ng/0	involves: C57BL/6 * C57BL/6N	MGI:7545187

Genotype
MGI:7545183

hm1

• Allelic Composition: Elac2^em1Afi/Elac2^em1Afi
• Genetic Background: C57BL/6N-Elac2^em1Afi

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal prostate gland anterior lobe morphology ( J:336403 )

• disarrayed nuclei at age 30 weeks

• branching into lumen at age 30 weeks

• grade 2 lesions at age 30 weeks

prostate gland anterior lobe hyperplasia ( J:336403 )

• at ages 10 and 30 weeks

abnormal prostate gland dorsolateral lobe morphology ( J:336403 )

• stromal thickening in dorsal lobe at age 10 weeks

• papillary structures protruding into lumen at age 30 weeks

• focal grade 2 lesions at age 30 weeks

• cell crowding at age 30 weeks

• normal lateral lobe morphology at ages 10 and 30 weeks

prostate gland dorsolateral lobe hyperplasia ( J:336403 )

• dorsal lobe at age 30 weeks

prostate gland hyperplasia ( J:336403 )

• hyperplasia of dorsal lobe at age 30 weeks and anterior lobes at ages 10 and 30 weeks

prostate gland inflammation ( J:336403 )

• at age 30 weeks

immune system

prostate gland inflammation ( J:336403 )

• at age 30 weeks

reproductive system

reproductive system phenotype ( J:336403 )

N • normal ventral and lateral lobe morphology at ages 10 and 30 weeks

abnormal prostate gland anterior lobe morphology ( J:336403 )

• disarrayed nuclei at age 30 weeks

• branching into lumen at age 30 weeks

• grade 2 lesions at age 30 weeks

prostate gland anterior lobe hyperplasia ( J:336403 )

• at ages 10 and 30 weeks

abnormal prostate gland dorsolateral lobe morphology ( J:336403 )

• stromal thickening in dorsal lobe at age 10 weeks

• papillary structures protruding into lumen at age 30 weeks

• focal grade 2 lesions at age 30 weeks

• cell crowding at age 30 weeks

• normal lateral lobe morphology at ages 10 and 30 weeks

prostate gland dorsolateral lobe hyperplasia ( J:336403 )

• dorsal lobe at age 30 weeks

prostate gland hyperplasia ( J:336403 )

• hyperplasia of dorsal lobe at age 30 weeks and anterior lobes at ages 10 and 30 weeks

prostate gland inflammation ( J:336403 )

• at age 30 weeks

mortality/aging

mortality/aging ( J:336403 )

N • normal lifespan

Genotype
MGI:7545187

cx2

• Allelic Composition: Elac2^em1Afi/Elac2^em1Afi; Tg(TRAMP)8247Ng/0
• Genetic Background: involves: C57BL/6 * C57BL/6N

endocrine/exocrine glands

prostate gland hyperplasia ( J:336403 )

• at age 30 weeks

increased prostate intraepithelial neoplasia incidence ( J:336403 )

• at ages 10 and 30 weeks

abnormal seminal vesicle epithelium morphology ( J:336403 )

• substantial tumor formation at age 30 weeks

dilated seminal vesicle ( J:336403 )

• engorged at age 30 weeks

mortality/aging

premature death ( J:336403 )

• fewer mice live past 30 weeks and increased number die after 30 weeks owing to tumor load

neoplasm

increased prostate intraepithelial neoplasia incidence ( J:336403 )

• at ages 10 and 30 weeks

reproductive system

prostate gland hyperplasia ( J:336403 )

• at age 30 weeks

increased prostate intraepithelial neoplasia incidence ( J:336403 )

• at ages 10 and 30 weeks

abnormal seminal vesicle epithelium morphology ( J:336403 )

• substantial tumor formation at age 30 weeks

dilated seminal vesicle ( J:336403 )

• engorged at age 30 weeks