All Phenotypes Wdfy4<em1Jkln> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Wdfy4^em1Jkln
endonuclease-mediated mutation 1, Justin Kline
MGI:7545162

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Wdfy4^em1Jkln/Wdfy4^em1Jkln	C57BL/6J-Wdfy4^em1Jkln	MGI:7545236

Allelic Composition	Wdfy4^em1Jkln/Wdfy4^em1Jkln
Genetic Background	C57BL/6J-Wdfy4^em1Jkln

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wdfy4^em1Jkln mutation (0 available); any Wdfy4 mutation (142 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:326216 )

N	• mice exhibit normal numbers of T cells in secondary lymphoid organs

decreased dendritic cell number ( J:326216 )

• reduced CD103+ CD11b^neg migratory cDC1 cells in the mesenteric lymph nodes

neoplasm

increased tumor growth/size ( J:326216 )

• mice fail to reject 1969 sarcoma cells unlike wild-type mice

hematopoietic system

decreased dendritic cell number ( J:326216 )

• reduced CD103+ CD11b^neg migratory cDC1 cells in the mesenteric lymph nodes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24