Phenotypes associated with this allele

• Allele Symbol: Lepr^db-Nokl
• Allele Name: diabetes Nora Kloeting
• Allele ID: MGI:7545269
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lepr^db-Nokl/Lepr^db-Nokl	C57BL/6N-Lepr^db-Nokl	MGI:7545546
ht2	Lepr^db/Lepr^db-Nokl	B6NTac.Cg-Lepr^db Lepr^db-Nokl	MGI:7545554

Genotype
MGI:7545546

hm1

• Allelic Composition: Lepr^db-Nokl/Lepr^db-Nokl
• Genetic Background: C57BL/6N-Lepr^db-Nokl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

male infertility ( J:313303 )

♂

adipose tissue

increased subcutaneous adipose tissue amount ( J:313303 )

increased body fat mass ( J:313303 )

increased white fat cell size ( J:313303 )

increased gonadal fat pad weight ( J:313303 )

behavior/neurological

increased food intake ( J:313303 )

abnormal locomotor circadian rhythm ( J:313303 )

• no activity, oxygen consumption and carbon dioxide production difference between light and dark periods

decreased locomotor activity ( J:313303 )

• constant low activity regardless of light or dark period

growth/size/body

increased body fat mass ( J:313303 )

obese ( J:313303 )

hematopoietic system

increased glycosylated hemoglobin level ( J:313303 )

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:313303 )

N • normal circulating adiponectin and post-fasting glucose levels in males

N • normal core body temperature in males

N • normal hepatic glycogen content in males and females

increased glycosylated hemoglobin level ( J:313303 )

increased fasting circulating glucose level ( J:313303 )

♀ • higher post-fasting circulating glucose levels in females

increased circulating insulin level ( J:313303 )

• higher fasting serum insulin levels

increased circulating leptin level ( J:313303 )

increased circulating cholesterol level ( J:313303 )

increased circulating HDL cholesterol level ( J:313303 )

increased circulating LDL cholesterol level ( J:313303 )

increased circulating triglyceride level ( J:313303 )

decreased core body temperature ( J:313303 )

♀ • higher core body temperature in females

abnormal carbon dioxide production ( J:313303 )

• steady production regardless of light or dark period

abnormal oxygen consumption ( J:313303 )

• steady consumption regardless of light or dark period

impaired glucose tolerance ( J:313303 )

• higher glucose levels after glucose injection

decreased circulating adiponectin level ( J:313303 )

♀ • lower circulating adiponectin levels in females

increased liver triglyceride level ( J:313303 )

increased susceptibility to diet-induced non-insulin dependent diabetes ( J:313303 )

abnormal peptide metabolism ( J:313303 )

integument

increased subcutaneous adipose tissue amount ( J:313303 )

limbs/digits/tail

short tail ( J:313303 )

liver/biliary system

increased liver triglyceride level ( J:313303 )

increased susceptibility to diet-induced hepatic steatosis ( J:313303 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
obesity		DOID:9970	OMIM:601665	J:313303

Genotype
MGI:7545554

ht2

• Allelic Composition: Lepr^db/Lepr^db-Nokl
• Genetic Background: B6NTac.Cg-Lepr^db Lepr^db-Nokl

adipose tissue

increased subcutaneous adipose tissue amount ( J:313303 )

increased body fat mass ( J:313303 )

increased white fat cell size ( J:313303 )

increased gonadal fat pad weight ( J:313303 )

behavior/neurological

increased food intake ( J:313303 )

abnormal locomotor circadian rhythm ( J:313303 )

• no activity, oxygen consumption and carbon dioxide production difference between light and dark periods

decreased locomotor activity ( J:313303 )

• constant low activity regardless of light or dark period

growth/size/body

increased body fat mass ( J:313303 )

obese ( J:313303 )

hematopoietic system

increased glycosylated hemoglobin level ( J:313303 )

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:313303 )

N • normal circulating adiponectin and post-fasting glucose levels in males

N • normal core body temperature in males

N • normal hepatic glycogen content in males and females

increased glycosylated hemoglobin level ( J:313303 )

increased fasting circulating glucose level ( J:313303 )

♀ • higher post-fasting circulating glucose levels in females

increased circulating insulin level ( J:313303 )

• higher fasting serum insulin levels

increased circulating leptin level ( J:313303 )

increased circulating cholesterol level ( J:313303 )

increased circulating HDL cholesterol level ( J:313303 )

increased circulating LDL cholesterol level ( J:313303 )

increased circulating triglyceride level ( J:313303 )

decreased core body temperature ( J:313303 )

♀ • lower core body temperature in females

abnormal carbon dioxide production ( J:313303 )

• steady production regardless of light or dark period

abnormal oxygen consumption ( J:313303 )

• steady consumption regardless of light or dark period

impaired glucose tolerance ( J:313303 )

• higher glucose levels after glucose injection

decreased circulating adiponectin level ( J:313303 )

♀ • lower circulating adiponectin levels in females

increased liver triglyceride level ( J:313303 )

increased susceptibility to diet-induced non-insulin dependent diabetes ( J:313303 )

abnormal peptide metabolism ( J:313303 )

integument

increased subcutaneous adipose tissue amount ( J:313303 )

limbs/digits/tail

short tail ( J:313303 )

liver/biliary system

increased liver triglyceride level ( J:313303 )

increased susceptibility to diet-induced hepatic steatosis ( J:313303 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
obesity		DOID:9970	OMIM:601665	J:313303