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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fignl1tm1Osb
targeted mutation 1, Research Institute for Microbial Diseases, Osaka University
MGI:7546939
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Fignl1tm1Osb/Fignl1tm1.1Osb
Spo11tm1Mjn/Spo11tm1Mjn
Tg(Stra8-cre)1Osb/0 		involves: 129X1/SvJ * C57BL/6 MGI:7546968
cn2
 		Fignl1tm1Osb/Fignl1tm1.1Osb
Tg(Stra8-cre)1Osb/0 		involves: C57BL/6 MGI:7546966
cn3
 		Fignl1tm1Osb/Fignl1tm1.1Osb
Swsap1tm1.1Osb/Swsap1tm1.1Osb
Tg(Stra8-cre)1Osb/0 		involves: C57BL/6 MGI:7546969


Genotype
MGI:7546968
cn1
Allelic
Composition		 Fignl1tm1Osb/Fignl1tm1.1Osb
Spo11tm1Mjn/Spo11tm1Mjn
Tg(Stra8-cre)1Osb/0
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fignl1tm1.1Osb mutation (0 available); any Fignl1 mutation (61 available)
Fignl1tm1Osb mutation (0 available); any Fignl1 mutation (61 available)
Spo11tm1Mjn mutation (2 available); any Spo11 mutation (21 available)
Tg(Stra8-cre)1Osb mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
arrest of male meiosis ( J:342157 )
• cells are fully lost before pachynema

cellular
arrest of male meiosis ( J:342157 )
• cells are fully lost before pachynema




Genotype
MGI:7546966
cn2
Allelic
Composition		 Fignl1tm1Osb/Fignl1tm1.1Osb
Tg(Stra8-cre)1Osb/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fignl1tm1.1Osb mutation (0 available); any Fignl1 mutation (61 available)
Fignl1tm1Osb mutation (0 available); any Fignl1 mutation (61 available)
Tg(Stra8-cre)1Osb mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
oligozoospermia ( J:342157 )
• 6-fold lower than in control mice with reduced numbers of late spermatocytes and spermatids
arrest of male meiosis ( J:342157 )
• abnormal meiotic recombination with cells fully lost before pachynema

cellular
oligozoospermia ( J:342157 )
• 6-fold lower than in control mice with reduced numbers of late spermatocytes and spermatids
arrest of male meiosis ( J:342157 )
• abnormal meiotic recombination with cells fully lost before pachynema




Genotype
MGI:7546969
cn3
Allelic
Composition		 Fignl1tm1Osb/Fignl1tm1.1Osb
Swsap1tm1.1Osb/Swsap1tm1.1Osb
Tg(Stra8-cre)1Osb/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fignl1tm1.1Osb mutation (0 available); any Fignl1 mutation (61 available)
Fignl1tm1Osb mutation (0 available); any Fignl1 mutation (61 available)
Swsap1tm1.1Osb mutation (0 available); any Swsap1 mutation (16 available)
Tg(Stra8-cre)1Osb mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal male meiosis ( J:342157 )
• however, RAD51/DMC1 assembly defects observed in Swsap1tm1.1Osb homozygotes is rescued

cellular
abnormal male meiosis ( J:342157 )
• however, RAD51/DMC1 assembly defects observed in Swsap1tm1.1Osb homozygotes is rescued




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory