Analysis Tools
behavior/neurological
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• latencies to entering the shock compartment are significantly shorter compared to wild-type controls but are longer than training latencies
• responses in a hot plate test are similar to controls indicating similar pain sensitivities to controls
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• non-habituated males show attenuated exploration in an open field
• reduced exploratory activity (reduced nose pokes, time spent inspecting holes, and number of holes repeatedly poked) in the 16-hole board test
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• decrease in time spent exploring the open arm in an elevated plus maze and increased latency until first open arm entry
• however, total transitions between arms and between the light and dark sides is similar to wild-type controls
• decrease in the time spent in the light side during a light-dark box test
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nervous system
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• no gross anatomical changes in major brain structures and no alteration in the development, anatomical position, survival or number of neurons that normally express the protein
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