All Phenotypes Faap100<em1Jzc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Faap100^em1Jzc
endonuclease-mediated mutation 1, Zi-Jiang Chen
MGI:7548790

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Faap100^em1Jzc/Faap100^em1Jzc	involves: C57BL/6J * ICR	MGI:7548877
cx2	Faap100^em1Jzc/Faap100^em1Jzc Trp53^em1Cya/Trp53^em1Cya	involves: C57BL/6J * ICR	MGI:7548878

Allelic Composition	Faap100^em1Jzc/Faap100^em1Jzc
Genetic Background	involves: C57BL/6J * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Faap100^em1Jzc mutation (0 available); any Faap100 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

azoospermia ( J:339060 )

• at 3 months

decreased primordial germ cell number ( J:339060 )

• at E9.5 and E11.5

• however, normal numbers of cells are present at E8.5

increased primordial germ cell apoptosis ( J:339060 )

• 3.38-fold associated with increased DNA damage

decreased primordial germ cell proliferation ( J:339060 )

• reduced percentage of cells in S phase

abnormal ovarian follicle number ( J:339060 )

• reduced at birth, P3, and P21

absent ovarian follicles ( J:339060 )

• at 3 months

small ovary ( J:339060 )

decreased ovary weight ( J:339060 )

ovary atrophy ( J:339060 )

small testis ( J:339060 )

decreased testis weight ( J:339060 )

absent estrous cycle ( J:339060 )

homeostasis/metabolism

increased circulating follicle stimulating hormone level ( J:339060 )

• in female mice

endocrine/exocrine glands

abnormal ovarian follicle number ( J:339060 )

• reduced at birth, P3, and P21

absent ovarian follicles ( J:339060 )

• at 3 months

small ovary ( J:339060 )

decreased ovary weight ( J:339060 )

ovary atrophy ( J:339060 )

small testis ( J:339060 )

decreased testis weight ( J:339060 )

cellular

azoospermia ( J:339060 )

• at 3 months

decreased primordial germ cell number ( J:339060 )

• at E9.5 and E11.5

• however, normal numbers of cells are present at E8.5

increased primordial germ cell apoptosis ( J:339060 )

• 3.38-fold associated with increased DNA damage

decreased primordial germ cell proliferation ( J:339060 )

• reduced percentage of cells in S phase

Allelic Composition	Faap100^em1Jzc/Faap100^em1Jzc Trp53^em1Cya/Trp53^em1Cya
Genetic Background	involves: C57BL/6J * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Faap100^em1Jzc mutation (0 available); any Faap100 mutation (42 available)
Trp53^em1Cya mutation (1 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:339060 )

N	• unlike Faap100^em1Jzc homozygotes, mice exhibit normal primordial germ cell numbers at E11.5

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