All Phenotypes Faap100<em1Jzc> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Faap100^em1Jzc
endonuclease-mediated mutation 1, Zi-Jiang Chen
MGI:7548790

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Faap100^em1Jzc/Faap100^em1Jzc	involves: C57BL/6J * ICR	MGI:7548877
cx2	Faap100^em1Jzc/Faap100^em1Jzc Trp53^em1Cya/Trp53^em1Cya	involves: C57BL/6J * ICR	MGI:7548878

Allelic Composition	Faap100^em1Jzc/Faap100^em1Jzc
Genetic Background	involves: C57BL/6J * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Faap100^em1Jzc mutation (0 available); any Faap100 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

azoospermia ( J:339060 )

• at 3 months

decreased primordial germ cell number ( J:339060 )

• at E9.5 and E11.5

• however, normal numbers of cells are present at E8.5

increased primordial germ cell apoptosis ( J:339060 )

• 3.38-fold associated with increased DNA damage

decreased primordial germ cell proliferation ( J:339060 )

• reduced percentage of cells in S phase

abnormal ovarian follicle number ( J:339060 )

• reduced at birth, P3, and P21

absent ovarian follicles ( J:339060 )

• at 3 months

small ovary ( J:339060 )

decreased ovary weight ( J:339060 )

ovary atrophy ( J:339060 )

small testis ( J:339060 )

decreased testis weight ( J:339060 )

absent estrous cycle ( J:339060 )

homeostasis/metabolism

increased circulating follicle stimulating hormone level ( J:339060 )

• in female mice

endocrine/exocrine glands

abnormal ovarian follicle number ( J:339060 )

• reduced at birth, P3, and P21

absent ovarian follicles ( J:339060 )

• at 3 months

small ovary ( J:339060 )

decreased ovary weight ( J:339060 )

ovary atrophy ( J:339060 )

small testis ( J:339060 )

decreased testis weight ( J:339060 )

cellular

azoospermia ( J:339060 )

• at 3 months

decreased primordial germ cell number ( J:339060 )

• at E9.5 and E11.5

• however, normal numbers of cells are present at E8.5

increased primordial germ cell apoptosis ( J:339060 )

• 3.38-fold associated with increased DNA damage

decreased primordial germ cell proliferation ( J:339060 )

• reduced percentage of cells in S phase

Allelic Composition	Faap100^em1Jzc/Faap100^em1Jzc Trp53^em1Cya/Trp53^em1Cya
Genetic Background	involves: C57BL/6J * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Faap100^em1Jzc mutation (0 available); any Faap100 mutation (42 available)
Trp53^em1Cya mutation (1 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:339060 )

N	• unlike Faap100^em1Jzc homozygotes, mice exhibit normal primordial germ cell numbers at E11.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24