Phenotypes associated with this allele

• Allele Symbol: Crygc^M2J
• Allele Name: mutation 2 Jackson
• Allele ID: MGI:7549103
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Crygc^M2J/Crygc^M2J	B6(A)-Crygc^M2J/BocJ	MGI:7549285
ht2	Crygc^M2J/Crygc^+	B6(A)-Crygc^M2J/BocJ	MGI:7550444

Genotype
MGI:7549285

hm1

• Allelic Composition: Crygc^M2J/Crygc^M2J
• Genetic Background: B6(A)-Crygc^M2J/BocJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal lens morphology ( J:341260 )

• Decreased levels and aberrant staining of alphaA and betaB1 crystallins, GJA3, and GJA8 is found, there is a scarcity of gap junctions between lens fiber cells, lenses have decreased gap junctional conductance, and calcium phosphate, in the form of apatite, is found in the lenses.

abnormal lens fiber morphology ( J:341260 )

• At 10 days of age homozygous lens fiber cells in the nuclear region are variable in size, shape and organization and show some failed denucleation

cataract ( J:341260 )

• pronounced central cataract surrounded by multiple little opacities in a shamrock-like formation between the cortex and nucleus visible at 23 days

nuclear cataract ( J:341260 )

Genotype
MGI:7550444

ht2

• Allelic Composition: Crygc^M2J/Crygc⁺
• Genetic Background: B6(A)-Crygc^M2J/BocJ

vision/eye

abnormal lens morphology ( J:341260 )

• decreased denucleation compared with wild type and mild disturbances to the central lens compared with homozygotes

cataract ( J:341260 )

• heterozygotes develop minor nuclear opacities encircled by a halo, with the age of onset between 60 and 90 days, and although this phenotype worsens with age the heterozygous lens opacities remain far more mild than those in young homozygotes.

nuclear cataract ( J:341260 )