Phenotypes associated with this allele

• Allele Symbol: Frmd8^em2Smoc
• Allele Name: endonuclease-mediated mutation 2, Shanghai Model Organisms Center
• Allele ID: MGI:7549274
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Frmd8^em2Smoc/Frmd8^em2Smoc Tg(Vil1-cre)997Gum/0	involves: C57BL/6J * SJL	MGI:7549294

Genotype
MGI:7549294

cn1

• Allelic Composition: Frmd8^em2Smoc/Frmd8^em2Smoc; Tg(Vil1-cre)997Gum/0
• Genetic Background: involves: C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to colitis induced morbidity/mortality ( J:338904 )

• in AOM/DSS-treated mice

digestive/alimentary system

increased colon length ( J:338904 )

• in AOM/DSS-treated mice

increased susceptibility to induced colitis ( J:338904 )

• AOM/DSS-treated mice exhibit increased weight loss, increased tumor burden, shortened colorectum length, and poor survival associated with increased intestinal mucosal barrier damage compared with control mice

increased susceptibility to colitis induced morbidity/mortality ( J:338904 )

• in AOM/DSS-treated mice

neoplasm

increased incidence of tumors by chemical induction ( J:338904 )

• AOM/DSS-treated mice exhibit increased total tumor count and tumor burden with more adenoma formation compared with control mice

growth/size/body

increased susceptibility to weight loss ( J:338904 )

• in AOM/DSS-treated mice

increased spleen weight ( J:338904 )

• with greater lymphocyte infiltration in AOM/DSS-treated mice

hematopoietic system

increased spleen weight ( J:338904 )

• with greater lymphocyte infiltration in AOM/DSS-treated mice

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:338904 )

• AOM/DSS-treated mice exhibit increased total tumor count and tumor burden with more adenoma formation compared with control mice

immune system

increased susceptibility to induced colitis ( J:338904 )

• AOM/DSS-treated mice exhibit increased weight loss, increased tumor burden, shortened colorectum length, and poor survival associated with increased intestinal mucosal barrier damage compared with control mice

increased susceptibility to colitis induced morbidity/mortality ( J:338904 )

• in AOM/DSS-treated mice

increased spleen weight ( J:338904 )

• with greater lymphocyte infiltration in AOM/DSS-treated mice