All Phenotypes Tbl1xr1<tm1.1Meln> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tbl1xr1^tm1.1Meln
targeted mutation 1.1, Ari Melnick
MGI:7550437

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ighg1^tm1(cre)Cgn/Ighg1⁺ Tbl1xr1^tm1.1Meln/Tbl1xr1⁺	involves: 129P2/OlaHsd * C57BL/6J	MGI:7550771

Allelic Composition	Ighg1^tm1(cre)Cgn/Ighg1⁺ Tbl1xr1^tm1.1Meln/Tbl1xr1⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighg1^tm1(cre)Cgn mutation (3 available); any Ighg1 mutation (28 available)
Tbl1xr1^tm1.1Meln mutation (0 available); any Tbl1xr1 mutation (321 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal B cell differentiation ( J:292118 )

• decreased number and proportion of FAS+ GL7+and FAS+ CD38- germinal center B cells (GCBs) after immunization with sheep red blood cells (SRBC)

• normal B cell abundance

abnormal spleen morphology ( J:292118 )

• smaller germinal centers (GCs) after immunization with sheep red blood cells (SRBC)

• normal follicular structure and number of GCs after immunization with sheep red blood cells (SRBC)

immune system