mortality/aging
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• reduced survival rate in aged mice
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immune system
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• increase in the CD8+ T cell subset in the spleen and liver in aged mice
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• increase in the percentage of effector memory (CD62L- CD44+) T cells in aged mice
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• decrease in the percentage of naive (CD62L+ CD44-) T cells in aged mice
• difference is more pronounced in the CD8+ T cell compartment
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• significant decrease in the percentage of T reg cells in the live and slight reduction in the spleen at 14 months of age
• however, no change in T reg percentage is seen in young mice
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• transfection of T reg cells from aged mice into Rag null mice indicates that the ability of these cells to control T cell proliferation is impaired
• oxygen consumption rate is markedly suppressed in aged but not young T reg cells indicating mitochondrial dysfunction
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• substantial increase in the liver and smaller increase in the spleen at 14 months of age
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• in aged mice
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neoplasm
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• at 18 months of age
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homeostasis/metabolism
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• at 14 months of age
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liver/biliary system
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• aged mice (14 months) show more severe hepatic damage compared to age matched controls
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• increase in steatotic hepatocytes, inflammation and fat accumulation in the liver following 8 months on a high fat diet
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• increased at 14 months of age compared to age matched controls
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• at 18 months of age
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cellular
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• decreased mitochondrial mass in aged T reg cells
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• decreased length of mitochondria in T reg cells from aged mice
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• substantial increase in the liver and smaller increase in the spleen at 14 months of age
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• decrease in mitochondrial membrane potential in aged but not young T reg cells
• increase in reactive oxygen species in aged but not young T reg cells
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hematopoietic system
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• increase in the CD8+ T cell subset in the spleen and liver in aged mice
|
|
• increase in the percentage of effector memory (CD62L- CD44+) T cells in aged mice
|
|
• decrease in the percentage of naive (CD62L+ CD44-) T cells in aged mice
• difference is more pronounced in the CD8+ T cell compartment
|
|
• significant decrease in the percentage of T reg cells in the live and slight reduction in the spleen at 14 months of age
• however, no change in T reg percentage is seen in young mice
|
|
• transfection of T reg cells from aged mice into Rag null mice indicates that the ability of these cells to control T cell proliferation is impaired
• oxygen consumption rate is markedly suppressed in aged but not young T reg cells indicating mitochondrial dysfunction
|
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• substantial increase in the liver and smaller increase in the spleen at 14 months of age
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