Analysis Tools
mortality/aging
 |
• reduced survival rate in aged mice
|
immune system
|
|
• increase in the CD8+ T cell subset in the spleen and liver in aged mice
|
|
|
• increase in the percentage of effector memory (CD62L- CD44+) T cells in aged mice
|
|
|
• decrease in the percentage of naive (CD62L+ CD44-) T cells in aged mice
• difference is more pronounced in the CD8+ T cell compartment
|
|
|
• significant decrease in the percentage of T reg cells in the live and slight reduction in the spleen at 14 months of age
• however, no change in T reg percentage is seen in young mice
|
|
|
• transfection of T reg cells from aged mice into Rag null mice indicates that the ability of these cells to control T cell proliferation is impaired
• oxygen consumption rate is markedly suppressed in aged but not young T reg cells indicating mitochondrial dysfunction
|
|
|
• substantial increase in the liver and smaller increase in the spleen at 14 months of age
|
|
|
• in aged mice
|
neoplasm
|
|
• at 18 months of age
|
homeostasis/metabolism
|
|
• at 14 months of age
|
liver/biliary system
|
|
• aged mice (14 months) show more severe hepatic damage compared to age matched controls
|
|
|
• at 18 months of age
|
|
|
• increase in steatotic hepatocytes, inflammation and fat accumulation in the liver following 8 months on a high fat diet
|
|
|
• increased at 14 months of age compared to age matched controls
|
cellular
|
|
• decreased mitochondrial mass in aged T reg cells
|
|
|
• decreased length of mitochondria in T reg cells from aged mice
|
|
|
• substantial increase in the liver and smaller increase in the spleen at 14 months of age
|
|
|
• decrease in mitochondrial membrane potential in aged but not young T reg cells
• increase in reactive oxygen species in aged but not young T reg cells
|
hematopoietic system
|
|
• increase in the CD8+ T cell subset in the spleen and liver in aged mice
|
|
|
• increase in the percentage of effector memory (CD62L- CD44+) T cells in aged mice
|
|
|
• decrease in the percentage of naive (CD62L+ CD44-) T cells in aged mice
• difference is more pronounced in the CD8+ T cell compartment
|
|
|
• significant decrease in the percentage of T reg cells in the live and slight reduction in the spleen at 14 months of age
• however, no change in T reg percentage is seen in young mice
|
|
|
• transfection of T reg cells from aged mice into Rag null mice indicates that the ability of these cells to control T cell proliferation is impaired
• oxygen consumption rate is markedly suppressed in aged but not young T reg cells indicating mitochondrial dysfunction
|
|
|
• substantial increase in the liver and smaller increase in the spleen at 14 months of age
|
