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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Api5em1Cad
endonuclease-mediated mutation 1, Ken Cadwell
MGI:7563901
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Api5em1Cad/Api5em1Cad
Atg16l1tm1c(EUCOMM)Wtsi/Atg16l1tm1c(EUCOMM)Wtsi
Tg(Vil1-cre)997Gum/0 		involves: C57BL/6J * C57BL/6N * SJL MGI:7564119
cn2
 		Api5em1Cad/Api5+
Atg16l1tm1c(EUCOMM)Wtsi/Atg16l1tm1c(EUCOMM)Wtsi
Tg(Vil1-cre)997Gum/0 		involves: C57BL/6J * C57BL/6N * SJL MGI:7564126


Genotype
MGI:7564119
cn1
Allelic
Composition		 Api5em1Cad/Api5em1Cad
Atg16l1tm1c(EUCOMM)Wtsi/Atg16l1tm1c(EUCOMM)Wtsi
Tg(Vil1-cre)997Gum/0
Genetic
Background		 involves: C57BL/6J * C57BL/6N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Api5em1Cad mutation (0 available); any Api5 mutation (33 available)
Atg16l1tm1c(EUCOMM)Wtsi mutation (0 available); any Atg16l1 mutation (44 available)
Tg(Vil1-cre)997Gum mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, incomplete penetrance ( J:340266 )
• fewer than expected are recovered




Genotype
MGI:7564126
cn2
Allelic
Composition		 Api5em1Cad/Api5+
Atg16l1tm1c(EUCOMM)Wtsi/Atg16l1tm1c(EUCOMM)Wtsi
Tg(Vil1-cre)997Gum/0
Genetic
Background		 involves: C57BL/6J * C57BL/6N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Api5em1Cad mutation (0 available); any Api5 mutation (33 available)
Atg16l1tm1c(EUCOMM)Wtsi mutation (0 available); any Atg16l1 mutation (44 available)
Tg(Vil1-cre)997Gum mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal Paneth cell morphology ( J:340266 )
• increased proportion of abnormal Paneth cells

endocrine/exocrine glands
abnormal Paneth cell morphology ( J:340266 )
• increased proportion of abnormal Paneth cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory