Phenotypes associated with this allele

• Allele Symbol: Mir10b^em1Rosay
• Allele Name: endonuclease-mediated mutation 1, Kenton M Sanders and Seungil Ro
• Allele ID: MGI:7564075
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mir10b^em1Rosay/Mir10b^em1Rosay	C57BL/6J-Mir10b^em1Rosay	MGI:7564143

Genotype
MGI:7564143

hm1

• Allelic Composition: Mir10b^em1Rosay/Mir10b^em1Rosay
• Genetic Background: C57BL/6J-Mir10b^em1Rosay

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased susceptibility to weight gain ( J:342486 )

♂ • males exhibit increased body weight gain

increased susceptibility to diet-induced obesity ( J:342486 )

• mice fed a high-fat and high-sucrose diet for 12 weeks gain body weight at a faster rate than wild-type mice

digestive/alimentary system

abnormal intestinal epithelium morphology ( J:342486 )

• the epithelium of the distal colon is extensively blunted

abnormal intestinal transit time ( J:342486 )

• mice develop extensively delayed whole gut transit, with increased whole gut transit times

• mice develop slow transit constipation as indicated by delayed colonic transit time

• treatment of 5-month-old mice with an miR-10b-5p mimic rescues gut dysmotility

impaired gastric peristalsis ( J:342486 )

• mice show reduced percentage of gastric emptying

abnormal intestine physiology ( J:342486 )

• mice show increased gut permeability

• treatment of 5-month-old mice with an miR-10b-5p mimic rescues leaky gut

large intestinal inflammation ( J:342486 )

• mice show severe epithelial erosion marked crypt damage, and increased inflammatory cell infiltration indicating colon inflammation

homeostasis/metabolism

increased susceptibility to diet-induced obesity ( J:342486 )

• mice fed a high-fat and high-sucrose diet for 12 weeks gain body weight at a faster rate than wild-type mice

hyperglycemia ( J:342486 )

• mice develop increased blood glucose levels after 20 weeks of age

• mice fed a high-fat and high-sucrose diet for 12 weeks experience an earlier onset of hyperglycemia than wild-type mice

• treatment of 5-month-old mice with an miR-10b-5p mimic rescues hyperglycemia

impaired glucose tolerance ( J:342486 )

• males show impaired glucose tolerance at 15, 30 60, 90, and 120 min after glucose injection

• females show impaired glucose tolerance at 60, 90, and 120 min after glucose injection

insulin resistance ( J:342486 )

immune system

large intestinal inflammation ( J:342486 )

• mice show severe epithelial erosion marked crypt damage, and increased inflammatory cell infiltration indicating colon inflammation