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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Swhtrtm1.1Phg
targeted mutation 1.1, Phillip Grote
MGI:7565401
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Swhtrtm1.1Phg/Swhtrtm1.1Phg either: (involves: C57BL/6J) or (involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac) MGI:7565493


Genotype
MGI:7565493
hm1
Allelic
Composition
Swhtrtm1.1Phg/Swhtrtm1.1Phg
Genetic
Background
either: (involves: C57BL/6J) or (involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac)
Find Mice Using the International Mouse Strain Resource (IMSR)
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phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• male mice of 8 weeks of age show increased mortality after acute myocardial infarction
• following acute myocardial infarction, the intraventricular septum does not show compensatory thickening as is seen in wild-type mice and cell size in the intraventricular septum is decreased indicating a defect in the hypertrophic response after cardiac injury
• however, size of myocardial infarction is similar to that in wild-type mice and cardiac function parameters do not significantly differ from wild-type
• mice exhibit normal heart function, with no differences in ejection fraction, heart rate, or left ventricular diameter

mortality/aging
• male mice of 8 weeks of age show increased mortality after acute myocardial infarction

homeostasis/metabolism
• male mice of 8 weeks of age show increased mortality after acute myocardial infarction
• following acute myocardial infarction, the intraventricular septum does not show compensatory thickening as is seen in wild-type mice and cell size in the intraventricular septum is decreased indicating a defect in the hypertrophic response after cardiac injury
• however, size of myocardial infarction is similar to that in wild-type mice and cardiac function parameters do not significantly differ from wild-type
• mice exhibit normal heart function, with no differences in ejection fraction, heart rate, or left ventricular diameter
• male mice of 8 weeks of age show increased mortality after acute myocardial infarction





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory