cardiovascular system
• male mice of 8 weeks of age show increased mortality after acute myocardial infarction
• following acute myocardial infarction, the intraventricular septum does not show compensatory thickening as is seen in wild-type mice and cell size in the intraventricular septum is decreased indicating a defect in the hypertrophic response after cardiac injury
• however, size of myocardial infarction is similar to that in wild-type mice and cardiac function parameters do not significantly differ from wild-type
• mice exhibit normal heart function, with no differences in ejection fraction, heart rate, or left ventricular diameter
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mortality/aging
• male mice of 8 weeks of age show increased mortality after acute myocardial infarction
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homeostasis/metabolism
• male mice of 8 weeks of age show increased mortality after acute myocardial infarction
• following acute myocardial infarction, the intraventricular septum does not show compensatory thickening as is seen in wild-type mice and cell size in the intraventricular septum is decreased indicating a defect in the hypertrophic response after cardiac injury
• however, size of myocardial infarction is similar to that in wild-type mice and cardiac function parameters do not significantly differ from wild-type
• mice exhibit normal heart function, with no differences in ejection fraction, heart rate, or left ventricular diameter
|
• male mice of 8 weeks of age show increased mortality after acute myocardial infarction
|