Phenotypes associated with this allele

• Allele Symbol: Mir501^tm1Rchen
• Allele Name: targeted mutation 1, Rongqing Chen
• Allele ID: MGI:7567435
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ot1	Mir501^tm1Rchen/Y	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:7567453

Genotype
MGI:7567453

ot1

• Allelic Composition: Mir501^tm1Rchen/Y
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal response to novel object ( J:343467 )

♂ • in a novel object recognition test mice prefer to spend less time with a novel object compared to a familiar object

♂ • treatment with MTEP a negative allosteric modulator of GRM5 improves novelty responses

abnormal response to social novelty ( J:343467 )

♂ • fail to prefer a stranger mouse over a familiar mouse

♂ • treatment with MTEP a negative allosteric modulator of GRM5 improves social novelty impairments

decreased social investigation ( J:343467 )

♂ • decreased preference for a stranger mouse compared to an empty cage or a familiar mouse

♂ • treatment with MTEP a negative allosteric modulator of GRM5 improves social investigation impairments

nervous system

decreased dendritic spine density ( J:343467 )

♂ • decrease of the total spine density in the hippocampal dentate gyrus region

abnormal dentate gyrus neuron dendrite morphology ( J:343467 )

♂ • display reduced dendritic complexity and growth

abnormal hippocampus physiology ( J:343467 )

♂ • CA1 pyramidal neurons show a lower action potential threshold but fire significantly more action potentials in response to depolarizing current injections

abnormal synaptic physiology ( J:343467 )

♂ • increased input resistance and decreased rheobase in hippocampal pyramidal neurons

increased excitatory postsynaptic current frequency ( J:343467 )

♂ • increased spontaneous EPSC frequency but not amplitude in pyramidal neurons

decreased paired-pulse inhibition ( J:343467 )

♂ • show lower PPI at 78, 82, 86, and 90 dB compared to wild-type littermates

♂ • treatment with MTEP a negative allosteric modulator of GRM5 improves PPI responses