skeleton
• osteoclast differentiation is inhibited, with inhibited multinucleated osteoclast formation
• during osteoclast differentiation, osteoclasts form actin rings but do not form actin belts and differentiation-related markers are reduced
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• bone resorption activity is reduced in osteoclasts
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• total bone mineral density is increased in 12-week-old females
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• in 12-week-old females
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• in 12-week-old females
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• percent bone volume/tissue volume (BV/TV) ratio is increased in in 12-week-old females
• BV/TV ratio does not change with age as in wild-type mice which show a decrease with age
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• trabecular number of the femur and lumbar vertebrae is increased in 12-week-old females
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• trabecular spacing of the femur is decreased in12-week-old females
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• bone mass is increased in young and aged females
• while bone mass decreases in wild-type females with age, it does not in mutant females, indicating prevention of bone mass loss during aging
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hematopoietic system
• osteoclast differentiation is inhibited, with inhibited multinucleated osteoclast formation
• during osteoclast differentiation, osteoclasts form actin rings but do not form actin belts and differentiation-related markers are reduced
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• bone resorption activity is reduced in osteoclasts
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immune system
• osteoclast differentiation is inhibited, with inhibited multinucleated osteoclast formation
• during osteoclast differentiation, osteoclasts form actin rings but do not form actin belts and differentiation-related markers are reduced
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• bone resorption activity is reduced in osteoclasts
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cellular
• osteoclast differentiation is inhibited, with inhibited multinucleated osteoclast formation
• during osteoclast differentiation, osteoclasts form actin rings but do not form actin belts and differentiation-related markers are reduced
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