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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tm4sf19em2Sjkm
endonuclease-mediated mutation 2, Seong-Jin Kim
MGI:7567667
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Tm4sf19em2Sjkm/Tm4sf19em2Sjkm C57BL/6J-Tm4sf19em2Sjkm MGI:7781798


Genotype
MGI:7781798
hm1
Allelic
Composition
Tm4sf19em2Sjkm/Tm4sf19em2Sjkm
Genetic
Background
C57BL/6J-Tm4sf19em2Sjkm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tm4sf19em2Sjkm mutation (0 available); any Tm4sf19 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• osteoclast differentiation is inhibited, with inhibited multinucleated osteoclast formation
• during osteoclast differentiation, osteoclasts form actin rings but do not form actin belts and differentiation-related markers are reduced
• bone resorption activity is reduced in osteoclasts
• total bone mineral density is increased in 12-week-old females
• in 12-week-old females
• percent bone volume/tissue volume (BV/TV) ratio is increased in in 12-week-old females
• BV/TV ratio does not change with age as in wild-type mice which show a decrease with age
• trabecular number of the femur and lumbar vertebrae is increased in 12-week-old females
• trabecular spacing of the femur is decreased in12-week-old females
• bone mass is increased in young and aged females
• while bone mass decreases in wild-type females with age, it does not in mutant females, indicating prevention of bone mass loss during aging

hematopoietic system
• osteoclast differentiation is inhibited, with inhibited multinucleated osteoclast formation
• during osteoclast differentiation, osteoclasts form actin rings but do not form actin belts and differentiation-related markers are reduced
• bone resorption activity is reduced in osteoclasts

immune system
• osteoclast differentiation is inhibited, with inhibited multinucleated osteoclast formation
• during osteoclast differentiation, osteoclasts form actin rings but do not form actin belts and differentiation-related markers are reduced
• bone resorption activity is reduced in osteoclasts

cellular
• osteoclast differentiation is inhibited, with inhibited multinucleated osteoclast formation
• during osteoclast differentiation, osteoclasts form actin rings but do not form actin belts and differentiation-related markers are reduced





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory