Phenotypes associated with this allele

• Allele Symbol: Tm4sf19^em2Sjkm
• Allele Name: endonuclease-mediated mutation 2, Seong-Jin Kim
• Allele ID: MGI:7567667
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tm4sf19^em2Sjkm/Tm4sf19^em2Sjkm	C57BL/6J-Tm4sf19^em2Sjkm	MGI:7781798

Genotype
MGI:7781798

hm1

• Allelic Composition: Tm4sf19^em2Sjkm/Tm4sf19^em2Sjkm
• Genetic Background: C57BL/6J-Tm4sf19^em2Sjkm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal osteoclast differentiation ( J:343322 )

• osteoclast differentiation is inhibited, with inhibited multinucleated osteoclast formation

• during osteoclast differentiation, osteoclasts form actin rings but do not form actin belts and differentiation-related markers are reduced

abnormal osteoclast physiology ( J:343322 )

• bone resorption activity is reduced in osteoclasts

increased bone mineral density ( J:343322 )

♀ • total bone mineral density is increased in 12-week-old females

increased bone mineral density of lumbar vertebrae ( J:343322 )

♀ • in 12-week-old females

increased bone mineral density of femur ( J:343322 )

♀ • in 12-week-old females

increased bone volume ( J:343322 )

♀ • percent bone volume/tissue volume (BV/TV) ratio is increased in in 12-week-old females

♀ • BV/TV ratio does not change with age as in wild-type mice which show a decrease with age

increased bone trabecula number ( J:343322 )

♀ • trabecular number of the femur and lumbar vertebrae is increased in 12-week-old females

decreased bone trabecular spacing ( J:343322 )

♀ • trabecular spacing of the femur is decreased in12-week-old females

increased bone mass ( J:343322 )

♀ • bone mass is increased in young and aged females

♀ • while bone mass decreases in wild-type females with age, it does not in mutant females, indicating prevention of bone mass loss during aging

increased trabecular bone mass ( J:343322 )

♀

hematopoietic system

abnormal osteoclast differentiation ( J:343322 )

• osteoclast differentiation is inhibited, with inhibited multinucleated osteoclast formation

• during osteoclast differentiation, osteoclasts form actin rings but do not form actin belts and differentiation-related markers are reduced

abnormal osteoclast physiology ( J:343322 )

• bone resorption activity is reduced in osteoclasts

immune system

abnormal osteoclast differentiation ( J:343322 )

• osteoclast differentiation is inhibited, with inhibited multinucleated osteoclast formation

• during osteoclast differentiation, osteoclasts form actin rings but do not form actin belts and differentiation-related markers are reduced

abnormal osteoclast physiology ( J:343322 )

• bone resorption activity is reduced in osteoclasts

cellular

abnormal osteoclast differentiation ( J:343322 )

• osteoclast differentiation is inhibited, with inhibited multinucleated osteoclast formation

• during osteoclast differentiation, osteoclasts form actin rings but do not form actin belts and differentiation-related markers are reduced