Phenotypes associated with this allele

• Allele Symbol: Atp6v1b2^em1Pcamp
• Allele Name: endonuclease-mediated mutation 1, Philippe M Campeau
• Allele ID: MGI:7567698
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Atp6v1b2^em1Pcamp/Atp6v1b2^em1Pcamp	C57BL/6N-Atp6v1b2^em1Pcamp	MGI:7567701
ht2	Atp6v1b2^em1Pcamp/Atp6v1b2^+	C57BL/6N-Atp6v1b2^em1Pcamp	MGI:7567700

Genotype
MGI:7567701

hm1

• Allelic Composition: Atp6v1b2^em1Pcamp/Atp6v1b2^em1Pcamp
• Genetic Background: C57BL/6N-Atp6v1b2^em1Pcamp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:342781 )

N • normal grip strength

N • normal contextual and cued learning and memory

N • no spontaneous seizures

increased susceptibility to pharmacologically induced seizures ( J:342781 )

• lower PTZ-induced seizure threshold and seizure latency

decreased thigmotaxis ( J:342781 )

• more frequent entry into and more time spent in center of arena in open field test

• more time spent in light zone and more transitions between zones in light-dark test

increased locomotor activity ( J:342781 )

• greater distance travelled in open field test and light-dark test

environmentally induced seizures ( J:342781 )

• seizures induced by handling

embryo

embryo phenotype ( J:342781 )

N • born at normal Mendelian ratios

growth/size/body

abnormal birth body size ( J:342781 )

• lower body weight

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:342781 )

N • normal auditory brainstem response (ABR) at age 14 weeks

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:342781 )

N • normal glucose tolerance and clinical blood biochemistry parameters

mortality/aging

mortality/aging ( J:342781 )

N • viable

nervous system

nervous system phenotype ( J:342781 )

N • normal prepulse inhibition (PPI)

increased susceptibility to pharmacologically induced seizures ( J:342781 )

• lower PTZ-induced seizure threshold and seizure latency

environmentally induced seizures ( J:342781 )

• seizures induced by handling

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
epilepsy		DOID:1826		J:342781

Genotype
MGI:7567700

ht2

• Allelic Composition: Atp6v1b2^em1Pcamp/Atp6v1b2⁺
• Genetic Background: C57BL/6N-Atp6v1b2^em1Pcamp

behavior/neurological

behavior/neurological phenotype ( J:342781 )

N • no stimuli-induced or spontaneous seizures

increased susceptibility to pharmacologically induced seizures ( J:342781 )

• lower PTZ-induced seizure threshold and seizure latency

embryo

embryo phenotype ( J:342781 )

N • born at normal Mendelian ratios

growth/size/body

abnormal birth body size ( J:342781 )

• lower body weight

mortality/aging

mortality/aging ( J:342781 )

N • viable

nervous system

increased susceptibility to pharmacologically induced seizures ( J:342781 )

• lower PTZ-induced seizure threshold and seizure latency