Analysis Tools
mortality/aging
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• neutrophil-depleted or cyclophosphamide-treated mice infected with Aspergillus fumigatus show increased survival compared to controls
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immune system
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• mice exposed to bleomycin-induced lung injury show a decrease in lymphocyte populations in the lungs
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• mice exposed to bleomycin-induced lung injury show a decrease in TNF level in lavage fluid
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• neutrophil-depleted mice infected with Aspergillus fumigatus show reduced inflammatory cytokine production
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• inflammatory cytokines are increased in immune-competent mice after fungal aspiration
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• mice exposed to bleomycin-induced lung injury show a drop in CD4+ T cell-secreted IFN-gamma at the initial stage of injury
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• neutrophil-depleted or cyclophosphamide-treated mice infected with Aspergillus fumigatus show decreased susceptibility to invasive pulmonary aspergillosis, showing decreased fungal burden in the lungs of neutrophil-depleted mice, reduced inflammatory cytokine production, decreased lung pathology and lung tissue inflammation with decreased leukocyte infiltration, decreased lung leakage and increased fungal clearance
• however, airway inflammatory cells are not decreased
• however, immune-competent mice challenged with A. fumigatus conidia Af293 and a more virulent CEA10 strain do not show decreased fungal burden but show increased inflammatory cytokine gene expression compared to wild-type mice and neutropenic mutant mice
• however, immune-competent mice subjected to systemic fungal infection via retro-orbital infection with A. fumigatus show no difference in mortality or fungal burden in the lungs, liver, kidneys, brain and spleen compared to wild-type mice
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• neutrophil-depleted or cyclophosphamide-treated mice infected with Aspergillus fumigatus show increased survival compared to controls
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homeostasis/metabolism
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• mice exposed to bleomycin-induced lung injury show a decrease in TNF level in lavage fluid
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• neutrophil-depleted mice infected with Aspergillus fumigatus show reduced inflammatory cytokine production
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• inflammatory cytokines are increased in immune-competent mice after fungal aspiration
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• while mice exposed to bleomycin-induced lung injury show no differences from wild-type mice at days 6 and 13 postinjury, with no differences in airway leukocytes and lung cytokines, they do show decreased TNF in lavage fluid and a drop in CD4+ T cell-secreted IFN-gamma at the initial stage of injury, and a decrease in lymphocyte populations in the lungs, indicating no protection from lung injury
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hematopoietic system
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• mice exposed to bleomycin-induced lung injury show a decrease in lymphocyte populations in the lungs
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