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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tnfaip8l1em1Huwa
endonuclease-mediated mutation 1, Hui Wang
MGI:7567994
Summary 4 genotypes


Genotype
MGI:7568791
hm1
Allelic
Composition
Tnfaip8l1em1Huwa/Tnfaip8l1em1Huwa
Genetic
Background
C57BL/6-Tnfaip8l1em1Huwa
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfaip8l1em1Huwa mutation (0 available); any Tnfaip8l1 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• mice show exacerbated dextran sulfate sodium (DSS)-induced colitis, both acute and chronic, showing more severe colitis, greater body weight loss and delayed recovery, and shorter colons, increased inflammatory infiltrates with a more severe disruption of mucosal structures, increased cell death in colon and decreased intestinal epithelial cells (IEC) proliferation
• increased susceptibility to DSS-induced colitis is not due to microbiome shifts and bone marrow transplantation experiments indicate that nonhematopoietic cells are responsible for the severe colitis in mutants
• however, mice show normal enterocyte lineage allocation in the colon and normal architecture in resting conditions, normal number of goblet cells and mucus secretion, unaffected IEC proliferation and intestinal barrier permeability, no differences in microbial community alpha diversity and species composition
• mice with DSS-induced colitis begin to die on day 7 after DSS treatment and all die by day 13 compared to 50% of wild-type mice

immune system
• mice show exacerbated dextran sulfate sodium (DSS)-induced colitis, both acute and chronic, showing more severe colitis, greater body weight loss and delayed recovery, and shorter colons, increased inflammatory infiltrates with a more severe disruption of mucosal structures, increased cell death in colon and decreased intestinal epithelial cells (IEC) proliferation
• increased susceptibility to DSS-induced colitis is not due to microbiome shifts and bone marrow transplantation experiments indicate that nonhematopoietic cells are responsible for the severe colitis in mutants
• however, mice show normal enterocyte lineage allocation in the colon and normal architecture in resting conditions, normal number of goblet cells and mucus secretion, unaffected IEC proliferation and intestinal barrier permeability, no differences in microbial community alpha diversity and species composition
• mice with DSS-induced colitis begin to die on day 7 after DSS treatment and all die by day 13 compared to 50% of wild-type mice

mortality/aging
• mice with DSS-induced colitis begin to die on day 7 after DSS treatment and all die by day 13 compared to 50% of wild-type mice

neoplasm
N
• mice subjected to azoxymethane (AOM)/DSS (lower dose of DSS due to increased mortality) develop tumors to a similar extent as treated wild-type mice
• treatment of mice with AOM once a week for 6 consecutive weeks and aged for up to 24 weeks after last injection results in no differences in tumor formation from treated wild-type mice

growth/size/body
N
• normal body weight and colon length

hematopoietic system
N
• percentages and absolute numbers of myeloid cells, including macrophages, neutrophils, and dendritic cells in bone marrow, blood, and spleen are normal and development of CD4+ and CD8+ T cells and natural regulatory T cells in thymus, spleen, and mesenteric lymph nodes and activation status of CD4+ and CD8+ T cells are unaffected




Genotype
MGI:7568799
cx2
Allelic
Composition
Tnfaip8l1em1Huwa/Tnfaip8l1em1Huwa
Tnfrsf1aem2Smoc/Tnfrsf1aem2Smoc
Tnfrsf1bem1Smoc/Tnfrsf1bem1Smoc
Genetic
Background
C57BL/6-Tnfrsf1bem1Smoc Tnfrsf1aem2Smoc Tnfaip8l1em1Huwa
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfaip8l1em1Huwa mutation (0 available); any Tnfaip8l1 mutation (12 available)
Tnfrsf1aem2Smoc mutation (0 available); any Tnfrsf1a mutation (52 available)
Tnfrsf1bem1Smoc mutation (0 available); any Tnfrsf1b mutation (41 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
N
• mice show similar DSS-induced colitis as wild-type mice but less severe colitis symptoms than single Tnfaip8l1 homozygotes




Genotype
MGI:7568795
cx3
Allelic
Composition
ApcMin/Apc+
Tnfaip8l1em1Huwa/Tnfaip8l1em1Huwa
Genetic
Background
involves: C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (158 available)
Tnfaip8l1em1Huwa mutation (0 available); any Tnfaip8l1 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• survival of mice is comparable to that of single heterozygous ApcMin mice, with mice starting to die by 20 weeks of age and most dying by 30 weeks of age

digestive/alimentary system
• mice develop colon tumors and show no difference in tumor number or tumor load from that of single heterozygous ApcMin mice and no difference in formation of sporadic tumors is seen

neoplasm
• mice develop colon tumors and show no difference in tumor number or tumor load from that of single heterozygous ApcMin mice and no difference in formation of sporadic tumors is seen




Genotype
MGI:7568796
cx4
Allelic
Composition
Tnfaip8Gt(IST13629C1)Tigm/Tnfaip8Gt(IST13629C1)Tigm
Tnfaip8l1em1Huwa/Tnfaip8l1em1Huwa
Genetic
Background
involves: C57BL/6 * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfaip8Gt(IST13629C1)Tigm mutation (1 available); any Tnfaip8 mutation (18 available)
Tnfaip8l1em1Huwa mutation (0 available); any Tnfaip8l1 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice exhibit a hunched posture at 1 year of age

digestive/alimentary system
• inflammation in the lamina propria is occasionally organized into de novo lymphoid follicles
• lamina propria has increased frequency of Th17 cells
• the frequency of total CD45+ immune cells and MHC class II+CD19+ B lymphocytes is increased within the mucosa
• colons show elongation of colonic crypts
• multinucleated giant cells are detected in the colon
• 1-year-old mice have shorter colons
• mice begin to develop rectal prolapse by 40 weeks of age, and by 52 Weeks of age, about 50% of mice develop disease with rectal prolapse
• about 50% of mice develop spontaneous chronic colitis by 52 weeks of age
• colitis severity is variable and penetrance is incomplete

endocrine/exocrine glands
• colons show elongation of colonic crypts

growth/size/body
• mice show growth retardation, especially after 16 weeks of age and exhibit reduced body size at 1 year of age

hematopoietic system
• increase in circulating inflammatory leukocytes
• lamina propria has increased frequency of Th17 cells
• 1-year-old mice have decreased spleen weight

immune system
• about 50% of mice develop spontaneous chronic colitis by 52 weeks of age
• colitis severity is variable and penetrance is incomplete
• increase in circulating inflammatory leukocytes
• lamina propria has increased frequency of Th17 cells
• 1-year-old mice have decreased spleen weight

integument
• mice exhibit massy hair on the head and upper back at 1 year of age





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory