All Phenotypes Tnfaip8l1<em1Huwa> MGI Mouse

Phenotypes associated with this allele

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

increased susceptibility to induced colitis ( J:342074 )

• mice show exacerbated dextran sulfate sodium (DSS)-induced colitis, both acute and chronic, showing more severe colitis, greater body weight loss and delayed recovery, and shorter colons, increased inflammatory infiltrates with a more severe disruption of mucosal structures, increased cell death in colon and decreased intestinal epithelial cells (IEC) proliferation

• increased susceptibility to DSS-induced colitis is not due to microbiome shifts and bone marrow transplantation experiments indicate that nonhematopoietic cells are responsible for the severe colitis in mutants

• however, mice show normal enterocyte lineage allocation in the colon and normal architecture in resting conditions, normal number of goblet cells and mucus secretion, unaffected IEC proliferation and intestinal barrier permeability, no differences in microbial community alpha diversity and species composition

increased susceptibility to colitis induced morbidity/mortality ( J:342074 )

• mice with DSS-induced colitis begin to die on day 7 after DSS treatment and all die by day 13 compared to 50% of wild-type mice

immune system

increased susceptibility to induced colitis ( J:342074 )

increased susceptibility to colitis induced morbidity/mortality ( J:342074 )

• mice with DSS-induced colitis begin to die on day 7 after DSS treatment and all die by day 13 compared to 50% of wild-type mice

mortality/aging

increased susceptibility to colitis induced morbidity/mortality ( J:342074 )

• mice with DSS-induced colitis begin to die on day 7 after DSS treatment and all die by day 13 compared to 50% of wild-type mice

neoplasm

neoplasm ( J:342074 )

• mice subjected to azoxymethane (AOM)/DSS (lower dose of DSS due to increased mortality) develop tumors to a similar extent as treated wild-type mice

• treatment of mice with AOM once a week for 6 consecutive weeks and aged for up to 24 weeks after last injection results in no differences in tumor formation from treated wild-type mice

growth/size/body

growth/size/body region phenotype ( J:342074 )

N	• normal body weight and colon length

hematopoietic system

hematopoietic system phenotype ( J:342074 )

• percentages and absolute numbers of myeloid cells, including macrophages, neutrophils, and dendritic cells in bone marrow, blood, and spleen are normal and development of CD4+ and CD8+ T cells and natural regulatory T cells in thymus, spleen, and mesenteric lymph nodes and activation status of CD4+ and CD8+ T cells are unaffected

Allelic Composition	Tnfaip8l1^em1Huwa/Tnfaip8l1^em1Huwa Tnfrsf1a^em2Smoc/Tnfrsf1a^em2Smoc Tnfrsf1b^em1Smoc/Tnfrsf1b^em1Smoc
Genetic Background	C57BL/6-Tnfrsf1b^em1Smoc Tnfrsf1a^em2Smoc Tnfaip8l1^em1Huwa

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfaip8l1^em1Huwa mutation (0 available); any Tnfaip8l1 mutation (12 available)
Tnfrsf1a^em2Smoc mutation (0 available); any Tnfrsf1a mutation (52 available)
Tnfrsf1b^em1Smoc mutation (0 available); any Tnfrsf1b mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

digestive/alimentary phenotype ( J:342074 )

N	• mice show similar DSS-induced colitis as wild-type mice but less severe colitis symptoms than single Tnfaip8l1 homozygotes

Allelic Composition	Apc^Min/Apc⁺ Tnfaip8l1^em1Huwa/Tnfaip8l1^em1Huwa
Genetic Background	involves: C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^Min mutation (12 available); any Apc mutation (158 available)
Tnfaip8l1^em1Huwa mutation (0 available); any Tnfaip8l1 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:342074 )

• survival of mice is comparable to that of single heterozygous Apc^Min mice, with mice starting to die by 20 weeks of age and most dying by 30 weeks of age

digestive/alimentary system

increased colon tumor incidence ( J:342074 )

• mice develop colon tumors and show no difference in tumor number or tumor load from that of single heterozygous Apc^Min mice and no difference in formation of sporadic tumors is seen

neoplasm

increased colon tumor incidence ( J:342074 )

• mice develop colon tumors and show no difference in tumor number or tumor load from that of single heterozygous Apc^Min mice and no difference in formation of sporadic tumors is seen

Allelic Composition	Tnfaip8^{Gt(IST13629C1)Tigm}/Tnfaip8^{Gt(IST13629C1)Tigm} Tnfaip8l1^em1Huwa/Tnfaip8l1^em1Huwa
Genetic Background	involves: C57BL/6 * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfaip8^{Gt(IST13629C1)Tigm} mutation (1 available); any Tnfaip8 mutation (18 available)
Tnfaip8l1^em1Huwa mutation (0 available); any Tnfaip8l1 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

hunched posture ( J:342074 )

• mice exhibit a hunched posture at 1 year of age

digestive/alimentary system

abnormal intestinal mucosa morphology ( J:342074 )

• inflammation in the lamina propria is occasionally organized into de novo lymphoid follicles

• lamina propria has increased frequency of Th17 cells

• the frequency of total CD45+ immune cells and MHC class II+CD19+ B lymphocytes is increased within the mucosa

abnormal large intestine crypts of Lieberkuhn morphology ( J:342074 )

• colons show elongation of colonic crypts

abnormal colon morphology ( J:342074 )

• multinucleated giant cells are detected in the colon

decreased colon length ( J:342074 )

• 1-year-old mice have shorter colons

rectal prolapse ( J:342074 )

• mice begin to develop rectal prolapse by 40 weeks of age, and by 52 Weeks of age, about 50% of mice develop disease with rectal prolapse

colitis ( J:342074 )

• about 50% of mice develop spontaneous chronic colitis by 52 weeks of age

• colitis severity is variable and penetrance is incomplete

endocrine/exocrine glands

abnormal large intestine crypts of Lieberkuhn morphology ( J:342074 )

• colons show elongation of colonic crypts

growth/size/body

decreased body size ( J:342074 )

• mice show growth retardation, especially after 16 weeks of age and exhibit reduced body size at 1 year of age

hematopoietic system

increased leukocyte cell number ( J:342074 )

• increase in circulating inflammatory leukocytes

increased T-helper 17 cell number ( J:342074 )

• lamina propria has increased frequency of Th17 cells

decreased spleen weight ( J:342074 )

• 1-year-old mice have decreased spleen weight

immune system

colitis ( J:342074 )

• about 50% of mice develop spontaneous chronic colitis by 52 weeks of age

• colitis severity is variable and penetrance is incomplete

increased leukocyte cell number ( J:342074 )

• increase in circulating inflammatory leukocytes

increased T-helper 17 cell number ( J:342074 )

• lamina propria has increased frequency of Th17 cells

decreased spleen weight ( J:342074 )

• 1-year-old mice have decreased spleen weight

integument

abnormal coat appearance ( J:342074 )

• mice exhibit massy hair on the head and upper back at 1 year of age

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