Phenotypes associated with this allele

• Allele Symbol: Trim72^tm1Rpx
• Allele Name: targeted mutation 1, Rui-Ping Xiao
• Allele ID: MGI:7568835
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trim72^tm1Rpx/Trim72^tm1Rpx	involves: 129/SvJ * C57BL/6	MGI:7568838

Genotype
MGI:7568838

hm1

• Allelic Composition: Trim72^tm1Rpx/Trim72^tm1Rpx
• Genetic Background: involves: 129/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:342778 )

♂N • normal ventricular ejection fraction and left ventricular fractional shortening when fed high-fat diet (HFD)

♂N • no difference in infarct size in ischemia/reperfusion (I/R) experiments

growth/size/body

growth/size/body region phenotype ( J:342778 )

♂N • normal body weight

decreased susceptibility to diet-induced obesity ( J:342778 )

♂ • no obesity, smaller increase in organ fat deposits and no change in body fat/lean body weight ratio when fed high-fat diet (HFD)

♂ • attenuated declines in oxygen consumption and energy expenditure, with normal food and drink intake, when fed high-fat diet (HFD)

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:342778 )

♂N • normal basal glucose metabolism

decreased susceptibility to diet-induced obesity ( J:342778 )

♂ • no obesity, smaller increase in organ fat deposits and no change in body fat/lean body weight ratio when fed high-fat diet (HFD)

♂ • attenuated declines in oxygen consumption and energy expenditure, with normal food and drink intake, when fed high-fat diet (HFD)

decreased susceptibility to hyperlipidemia ( J:342778 )

♂ • no increase in non-esterified fatty acid or triglyceride when fed high-fat diet (HFD)

decreased susceptibility to diet-induced non-insulin dependent diabetes ( J:342778 )

♂ • no hyperglycemia, insulin resistance, glucose intolerance, and no increase in non-esterified fatty acid or triglyceride levels and attenuated enlargement of pancreatic islets when fed high-fat diet (HFD)

liver/biliary system

decreased susceptibility to diet-induced hepatic steatosis ( J:342778 )

♂ • no fatty liver when fed high-fat diet (HFD)

muscle

muscle phenotype ( J:342778 )

♂N • no changes to skeletal muscle morphology when fed high-fat diet (HFD)