Phenotypes associated with this allele

• Allele Symbol: Etv6^em3Knic
• Allele Name: endonuclease-mediated mutation 3, Kim E Nichols
• Allele ID: MGI:7568839
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Etv6^em3Knic/Etv6^+	involves: C57BL/6J	MGI:7569045

Genotype
MGI:7569045

ht1

• Allelic Composition: Etv6^em3Knic/Etv6⁺
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:342774 )

N • normal platelet numbers at age 3 months

N • normal numbers and ratios of mature myeloid cells at age 3 months

N • normal bone marrow cellularity at age 3 months

N • normal hematopoietic cell cycling and cell death at age 3 months

abnormal hemopoiesis ( J:342774 )

• functionally impaired hematopoietic stem and precursor cells (HSPCs): reduced contribution to B220+ CD19+ B cells and Gr1+ myeloid cells in competitive transplantation experiments

• normal T cell contribution in competitive transplantation experiments

abnormal platelet shape ( J:342774 )

• more rounded shape with greater surface area at age 3 months

abnormal B cell number ( J:342774 )

• increased proportion of B220+ CD19+ B cells in spleen, bone marrow and peripheral blood at age 3 months

abnormal hematopoietic precursor cell morphology ( J:342774 )

• increase in multipotent precursor 3 (MPP3) cell proportion and number and decrease in MPP4 cell proportion at age 3 months

• normal MPP4 cell number at age 3 months

abnormal common myeloid progenitor cell morphology ( J:342774 )

• decreased proportion of CMP cells at age 3 months

• normal number of CMP cells at age 3 months

homeostasis/metabolism

impaired blood coagulation ( J:342774 )

• delayed clot reaction at age 3 months

immune system

abnormal B cell number ( J:342774 )

• increased proportion of B220+ CD19+ B cells in spleen, bone marrow and peripheral blood at age 3 months