Phenotypes associated with this allele

• Allele Symbol: Slc39a8^em1Xijl
• Allele Name: endonuclease-mediated mutation 1, Xiong-Jian Luo
• Allele ID: MGI:7572529
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc39a8^em1Xijl/Slc39a8^em1Xijl	involves: C57BL/6J	MGI:7572560

Genotype
MGI:7572560

hm1

• Allelic Composition: Slc39a8^em1Xijl/Slc39a8^em1Xijl
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:342738 )

N • normal brain weight and neural stem cell proliferation and migration

N • normal mEPSC amplitude and frequency in hippocampal CA1 pyramidal neurons

decreased brain zinc level ( J:342738 )

decreased dendritic spine density ( J:342738 )

• in cortex

• normal in hippocampus

behavior/neurological

behavior/neurological phenotype ( J:342738 )

N • normal behavior and cognition in light-dark transition test, elevated plus maze, Y-maze, novel object recognition test, 3-chambered social approach test and tail suspension test

decreased locomotor activity ( J:342738 )

• reduced total distance and distance in corner in open-field test

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:342738 )

N • normal glucose, total cholesterol, triglyceride, HDL-C, and low-density lipoprotein cholesterol (LDL-C) levels in blood

decreased brain zinc level ( J:342738 )

increased circulating zinc level ( J:342738 )

growth/size/body

growth/size/body region phenotype ( J:342738 )

N • normal growth, length and body weight