Phenotypes associated with this allele

• Allele Symbol: Pklr^em1Appsc
• Allele Name: endonuclease-mediated mutation 1, Applied StemCell
• Allele ID: MGI:7572604
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pklr^em1Appsc/Pklr^em1Appsc	involves: C57BL/6J	MGI:7572609

Genotype
MGI:7572609

hm1

• Allelic Composition: Pklr^em1Appsc/Pklr^em1Appsc
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased saturated fatty acids level ( J:342736 )

• decreased percentage when fed high-sucrose diet (HSD) versus HSD-fed WT mice

abnormal sphingomyelin level ( J:342736 )

• lower liver sphingomyelin levels when fed high-sucrose diet (HSD) versus regular-chow-fed WT mice

• higher liver sphingomyelin levels when fed high-sucrose diet (HSD) versus HSD-fed WT mice

decreased ceramide level ( J:342736 )

• lower liver ceramide and galactosylceramide levels when fed high-sucrose diet (HSD) versus regular-chow-fed WT mice

abnormal metabolism ( J:342736 )

• higher liver phosphatidylcholine, phosphatidylethanolamine, sphingomyelin and lysophosphatidylcholine levels when fed high-sucrose diet (HSD) versus HSD-fed WT mice

• normal plasma cholesterol and triglyceride levels

liver/biliary system

decreased susceptibility to diet-induced hepatic steatosis ( J:342736 )

• lower liver triglyceride (TG) levels when fed high-sucrose diet (HSD)