Phenotypes associated with this allele

• Allele Symbol: Grb7^{tm1d(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1d, Wellcome Trust Sanger Institute
• Allele ID: MGI:7572892
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grb7^tm1d(EUCOMM)Wtsi/Grb7^tm1d(EUCOMM)Wtsi	involves: C57BL/6J * C57BL/6N	MGI:7593764

Genotype
MGI:7593764

hm1

• Allelic Composition: Grb7^{tm1d(EUCOMM)Wtsi}/Grb7^{tm1d(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6J * C57BL/6N
• Cell Lines: EPD0543_2_C04

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:344139 )

N • homozygotes are viable and survive to adulthood with no gross physical, behavioral or histopathological abnormalities

behavior/neurological

abnormal maternal behavior ( J:344139 )

• females fail to successfully raise pups to weaning age

cellular

maternal effect ( J:344139 )

• litters born to homozygous females fail to thrive to weaning age

• only 9% of litters born to homozygous females successfully yield at least one pup at P21; most or all of a litter commonly die in the early postnatal period (days 0-2)

• maternal success in litter raising does not improve with increasing parity

reproductive system

reproductive system phenotype ( J:344139 )

N • homozygotes are fertile

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:344139 )

N • mammary epithelial cells appear capable of synthesizing and secreting milk into mammary ducts; however, the nutritional content of milk and efficiency of milk ejection were not analyzed