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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Casp8em1Hbz
endonuclease-mediated mutation 1, Haibing Zhang
MGI:7572923
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Casp8em1Hbz/Casp8em1Hbz involves: C57BL/6 MGI:7573087
cx2
 		Casp8em1Hbz/Casp8em1Hbz
Ripk3tm1Xidw/Ripk3tm1Xidw 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:7573088
cx3
 		Casp8em1Hbz/Casp8em1Hbz
Ripk1em4Hbz/Ripk1em4Hbz
Ripk3tm1Xidw/Ripk3tm1Xidw 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:7573096
cx4
 		Casp8em1Hbz/Casp8em1Hbz
Ripk1em1Hbz/Ripk1em1Hbz
Ripk3tm1Xidw/Ripk3tm1Xidw 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:7573098
cx5
 		Casp8em1Hbz/Casp8em1Hbz
Mlklem1Hbz/Mlklem1Hbz 		involves: C57BL/6 MGI:7573092


Genotype
MGI:7573087
hm1
Allelic
Composition		 Casp8em1Hbz/Casp8em1Hbz
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp8em1Hbz mutation (0 available); any Casp8 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
enlarged spleen ( J:342732 )
• mild splenomegaly
decreased CD8-positive, alpha-beta T cell number ( J:342732 )
• mild decrease of CD8+ T cell percentage in spleen and bone marrow

homeostasis/metabolism
decreased circulating alanine transaminase level ( J:342732 )
• after treatment with anti-Fas antibody
decreased circulating aspartate transaminase level ( J:342732 )
• after treatment with anti-Fas antibody

cellular
decreased apoptosis ( J:342732 )
• resistance to apoptosis in mouse dermal fibroblasts (MDFs) after treatment with RIPK3 kinase inhibitor GSK872 in vitro
• compromised apoptosis in thymocytes in vitro and increased survival in vivo after treatment with anti-Fas antibody

hematopoietic system
hematopoietic system phenotype ( J:342732 )
N
• normal B cells and myeloid cells in spleen, lymph nodes and bone marrow
enlarged spleen ( J:342732 )
• mild splenomegaly
decreased CD8-positive, alpha-beta T cell number ( J:342732 )
• mild decrease of CD8+ T cell percentage in spleen and bone marrow

growth/size/body
enlarged spleen ( J:342732 )
• mild splenomegaly

mortality/aging
mortality/aging ( J:342732 )
N
• viable




Genotype
MGI:7573088
cx2
Allelic
Composition		 Casp8em1Hbz/Casp8em1Hbz
Ripk3tm1Xidw/Ripk3tm1Xidw
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp8em1Hbz mutation (0 available); any Casp8 mutation (45 available)
Ripk3tm1Xidw mutation (0 available); any Ripk3 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased granulocyte number ( J:342732 )
• increased CD11b+ granulocytes in spleen
• normal in bone marrow
increased CD11b-high dendritic cell number ( J:342732 )
• increased percentage of myeloid-derived CD11b+ cells in spleen and bone marrow
increased macrophage cell number ( J:342732 )
• in spleen
• normal in bone marrow
decreased leukocyte cell number ( J:342732 )
• decreased white blood cell number in peripheral blood
• normal monocyte and granulocyte numbers in peripheral blood
decreased lymphocyte cell number ( J:342732 )
• in peripheral blood
decreased B cell number ( J:342732 )
• severe reduction in CD19+ B cell numbers in spleen, bone marrow and peripheral blood
decreased mature B cell number ( J:342732 )
• reduced B220+ IgM+ and B220+ CD19+ B cell numbers in spleen, bone marrow and peripheral blood
decreased T cell number ( J:342732 )
• severe reduction in CD3+ T cell numbers in spleen, bone marrow and peripheral blood
• severe reduction in CD3+ CD4+ CD8- and CD3+ CD4- CD8+ T cell in spleen, bone marrow and peripheral blood

hematopoietic system
increased granulocyte number ( J:342732 )
• increased CD11b+ granulocytes in spleen
• normal in bone marrow
increased CD11b-high dendritic cell number ( J:342732 )
• increased percentage of myeloid-derived CD11b+ cells in spleen and bone marrow
increased macrophage cell number ( J:342732 )
• in spleen
• normal in bone marrow
decreased leukocyte cell number ( J:342732 )
• decreased white blood cell number in peripheral blood
• normal monocyte and granulocyte numbers in peripheral blood
decreased lymphocyte cell number ( J:342732 )
• in peripheral blood
decreased B cell number ( J:342732 )
• severe reduction in CD19+ B cell numbers in spleen, bone marrow and peripheral blood
decreased mature B cell number ( J:342732 )
• reduced B220+ IgM+ and B220+ CD19+ B cell numbers in spleen, bone marrow and peripheral blood
decreased T cell number ( J:342732 )
• severe reduction in CD3+ T cell numbers in spleen, bone marrow and peripheral blood
• severe reduction in CD3+ CD4+ CD8- and CD3+ CD4- CD8+ T cell in spleen, bone marrow and peripheral blood

growth/size/body
enlarged spleen ( J:342732 )




Genotype
MGI:7573096
cx3
Allelic
Composition		 Casp8em1Hbz/Casp8em1Hbz
Ripk1em4Hbz/Ripk1em4Hbz
Ripk3tm1Xidw/Ripk3tm1Xidw
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp8em1Hbz mutation (0 available); any Casp8 mutation (45 available)
Ripk1em4Hbz mutation (0 available); any Ripk1 mutation (33 available)
Ripk3tm1Xidw mutation (0 available); any Ripk3 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body size ( J:342732 )

integument
skin lesions ( J:342732 )
• focal cutaneous lesions

mortality/aging




Genotype
MGI:7573098
cx4
Allelic
Composition		 Casp8em1Hbz/Casp8em1Hbz
Ripk1em1Hbz/Ripk1em1Hbz
Ripk3tm1Xidw/Ripk3tm1Xidw
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp8em1Hbz mutation (0 available); any Casp8 mutation (45 available)
Ripk1em1Hbz mutation (0 available); any Ripk1 mutation (33 available)
Ripk3tm1Xidw mutation (0 available); any Ripk3 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased leukocyte cell number ( J:342732 )
• decreased white blood cell number in peripheral blood
• normal monocyte and granulocyte numbers in peripheral blood
decreased lymphocyte cell number ( J:342732 )
• in peripheral blood
decreased mature B cell number ( J:342732 )
• reduced B220+ IgM+ and B220+ CD19+ B cell numbers in spleen and bone marrow
decreased T cell number ( J:342732 )
• severe reduction in CD3+ CD4+ CD8- and CD3+ CD4- CD8+ T cell in spleen and bone marrow

immune system
decreased leukocyte cell number ( J:342732 )
• decreased white blood cell number in peripheral blood
• normal monocyte and granulocyte numbers in peripheral blood
decreased lymphocyte cell number ( J:342732 )
• in peripheral blood
decreased mature B cell number ( J:342732 )
• reduced B220+ IgM+ and B220+ CD19+ B cell numbers in spleen and bone marrow
decreased T cell number ( J:342732 )
• severe reduction in CD3+ CD4+ CD8- and CD3+ CD4- CD8+ T cell in spleen and bone marrow




Genotype
MGI:7573092
cx5
Allelic
Composition		 Casp8em1Hbz/Casp8em1Hbz
Mlklem1Hbz/Mlklem1Hbz
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp8em1Hbz mutation (0 available); any Casp8 mutation (45 available)
Mlklem1Hbz mutation (0 available); any Mlkl mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased granulocyte number ( J:342732 )
• increased CD11b+ granulocytes in spleen
• normal in bone marrow
increased CD11b-high dendritic cell number ( J:342732 )
• increased percentage of myeloid-derived CD11b+ cells in spleen and bone marrow
increased macrophage cell number ( J:342732 )
• in spleen
• normal in bone marrow
decreased leukocyte cell number ( J:342732 )
• decreased white blood cell number in peripheral blood
• normal monocyte and granulocyte numbers in peripheral blood
decreased lymphocyte cell number ( J:342732 )
• in peripheral blood
decreased B cell number ( J:342732 )
• severe reduction in CD19+ B cell numbers in spleen, bone marrow and peripheral blood
decreased mature B cell number ( J:342732 )
• reduced B220+ IgM+ and B220+ CD19+ B cell numbers in peripheral blood
decreased T cell number ( J:342732 )
• severe reduction in CD3+ T cell numbers in spleen, bone marrow and peripheral blood
• severe reduction in CD3+ CD4+ CD8- and CD3+ CD4- CD8+ T cell in peripheral blood

hematopoietic system
increased granulocyte number ( J:342732 )
• increased CD11b+ granulocytes in spleen
• normal in bone marrow
increased CD11b-high dendritic cell number ( J:342732 )
• increased percentage of myeloid-derived CD11b+ cells in spleen and bone marrow
increased macrophage cell number ( J:342732 )
• in spleen
• normal in bone marrow
decreased leukocyte cell number ( J:342732 )
• decreased white blood cell number in peripheral blood
• normal monocyte and granulocyte numbers in peripheral blood
decreased lymphocyte cell number ( J:342732 )
• in peripheral blood
decreased B cell number ( J:342732 )
• severe reduction in CD19+ B cell numbers in spleen, bone marrow and peripheral blood
decreased mature B cell number ( J:342732 )
• reduced B220+ IgM+ and B220+ CD19+ B cell numbers in peripheral blood
decreased T cell number ( J:342732 )
• severe reduction in CD3+ T cell numbers in spleen, bone marrow and peripheral blood
• severe reduction in CD3+ CD4+ CD8- and CD3+ CD4- CD8+ T cell in peripheral blood

growth/size/body
enlarged spleen ( J:342732 )




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11/12/2024
MGI 6.24 		The Jackson Laboratory