Phenotypes associated with this allele

• Allele Symbol: Filip1l^em1Slib
• Allele Name: endonuclease-mediated mutation 1, Steven K Libutti
• Allele ID: MGI:7578805
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Filip1l^em1Slib/Filip1l^em1Slib Tg(CDX2-cre/ERT2)752Erf/0	involves: C57BL/6J * SJL/J	MGI:7610140

Genotype
MGI:7610140

cn1

• Allelic Composition: Filip1l^em1Slib/Filip1l^em1Slib; Tg(CDX2-cre/ERT2)752Erf/0
• Genetic Background: involves: C57BL/6J * SJL/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal enterocyte proliferation ( J:312351 )

• after tamoxifen (TAM) induction, most cells of the elongated colonic crypts are Ki67-positive, indicating colonic epithelial hyperplasia

abnormal intestinal goblet cell physiology ( J:312351 )

• after TAM induction, colonic crypts exhibit significantly increased mRNA levels of markers for goblet cells (Muc2, Agr2) and secretory progenitors (Atoh1, Spdef and Neurog3), indicating increased mucin secretion

• however, mRNA levels of the stem cell marker Lgr5 are normal

abnormal large intestine crypts of Lieberkuhn morphology ( J:312351 )

• at 4 weeks after TAM induction, mice show significantly elongated crypts and compromised crypt integrity throughout the entire colon, with aberrant cell arrangements and irregular nuclei

• crypt elongation and loss of integrity is more evident in the proximal colon than in the mid to distal colon

• colonic crypts show a significant increase in Muc2 (mucin 2) expression

increased colon goblet cell number ( J:312351 )

• after TAM induction, colonic crypts exhibit significantly increased mRNA levels of markers for goblet cells (Muc2, Agr2)

cellular

increased colon goblet cell number ( J:312351 )

• after TAM induction, colonic crypts exhibit significantly increased mRNA levels of markers for goblet cells (Muc2, Agr2)

abnormal enterocyte proliferation ( J:312351 )

• after tamoxifen (TAM) induction, most cells of the elongated colonic crypts are Ki67-positive, indicating colonic epithelial hyperplasia

abnormal intestinal goblet cell physiology ( J:312351 )

• after TAM induction, colonic crypts exhibit significantly increased mRNA levels of markers for goblet cells (Muc2, Agr2) and secretory progenitors (Atoh1, Spdef and Neurog3), indicating increased mucin secretion

• however, mRNA levels of the stem cell marker Lgr5 are normal

endocrine/exocrine glands

abnormal large intestine crypts of Lieberkuhn morphology ( J:312351 )

• at 4 weeks after TAM induction, mice show significantly elongated crypts and compromised crypt integrity throughout the entire colon, with aberrant cell arrangements and irregular nuclei

• crypt elongation and loss of integrity is more evident in the proximal colon than in the mid to distal colon

• colonic crypts show a significant increase in Muc2 (mucin 2) expression

increased colon goblet cell number ( J:312351 )

• after TAM induction, colonic crypts exhibit significantly increased mRNA levels of markers for goblet cells (Muc2, Agr2)