Phenotypes associated with this allele

• Allele Symbol: Ints15^em1Takas
• Allele Name: endonuclease-mediated mutation 1, Shuji Takada
• Allele ID: MGI:7578876
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ints15^em1Takas/Ints15^em1Takas	involves: C57BL/6 * DBA/2	MGI:7628243
ht2	Ints15^em1Takas/Ints15^+	involves: C57BL/6 * DBA/2	MGI:7628244

Genotype
MGI:7628243

hm1

• Allelic Composition: Ints15^em1Takas/Ints15^em1Takas
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:337973 )

N • mice are born in accordance with Mendelian inheritance

vision/eye

abnormal eye morphology ( J:337973 )

• 49% of mice show local chorioretinal atrophy, characterized by defects of the choroid, deformity of the retinal layers, and gliosis

• however, no iris anomaly, Peters anomaly, or microphthalmos are observed

• no significant abnormalities are seen in other organs, such as brain, heart, lung, liver, intestine and kidney

abnormal retina blood vessel morphology ( J:337973 )

• 46% of mice exhibit narrowing of retinal vessels

• 43% of mice show sheathing of retinal vessels

increased retina hemangioma incidence ( J:337973 )

• 5% of mice exhibit hemangioma in retinal vessels

abnormal optic disk morphology ( J:337973 )

• 5% of mice exhibit an optic nerve head anomaly

• 17% of mice show a pigmentation phenotype in the optic nerve head

cornea opacity ( J:337973 )

• 2% of mice exhibit corneal opacity

cataract ( J:337973 )

• 7% of mice exhibit cataracts

abnormal eye development ( J:337973 )

• mice exhibit more severe ocular malformations in various eye tissues than heterozygous littermates

persistence of hyaloid vascular system ( J:337973 )

• 64% of mice exhibit persistence of ocular fetal vasculature (PFV), extending from the optic nerve head to the posterior surface of the lens and covering a large area in the vitreous cavity

abnormal retina layer morphology ( J:337973 )

• mice with local chorioretinal atrophy show deformity of the outer retinal layers with glial proliferation

• however, no retinal folds are observed

retina gliosis ( J:337973 )

• mice with local chorioretinal atrophy show glial proliferation around retinal vessels

abnormal optic choroid morphology ( J:337973 )

• mice with local chorioretinal atrophy show defects of the choroid

cardiovascular system

abnormal retina blood vessel morphology ( J:337973 )

• 46% of mice exhibit narrowing of retinal vessels

• 43% of mice show sheathing of retinal vessels

nervous system

abnormal optic disk morphology ( J:337973 )

• 5% of mice exhibit an optic nerve head anomaly

• 17% of mice show a pigmentation phenotype in the optic nerve head

neoplasm

increased retina hemangioma incidence ( J:337973 )

• 5% of mice exhibit hemangioma in retinal vessels

Genotype
MGI:7628244

ht2

• Allelic Composition: Ints15^em1Takas/Ints15⁺
• Genetic Background: involves: C57BL/6 * DBA/2

vision/eye

abnormal eye morphology ( J:337973 )

• 3% of mice show local chorioretinal atrophy

• however, no retinal folds, cataracts, corneal opacity, iris anomaly, Peters anomaly or microphthalmos are observed

abnormal retina blood vessel morphology ( J:337973 )

• 26% of mice exhibit narrowing of retinal vessels

• 7% of mice show sheathing of retinal vessels

• however, no retinal hemangioma is observed

abnormal optic disk morphology ( J:337973 )

• 14% of mice show a pigmentation phenotype in the optic nerve head

• however, no optic nerve head anomaly is observed

abnormal eye development ( J:337973 )

persistence of hyaloid vascular system ( J:337973 )

• 55% of mice show persistence of ocular fetal vasculature (PFV) on the optic nerve head

cardiovascular system

abnormal retina blood vessel morphology ( J:337973 )

• 26% of mice exhibit narrowing of retinal vessels

• 7% of mice show sheathing of retinal vessels

• however, no retinal hemangioma is observed

nervous system

abnormal optic disk morphology ( J:337973 )

• 14% of mice show a pigmentation phenotype in the optic nerve head

• however, no optic nerve head anomaly is observed