Analysis Tools
growth/size/body
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• after 10 wks of HFD feeding, mice show a significantly higher body weight than diet-matched wild-type controls
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adipose tissue
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• HFD-mice show significantly larger white adipocyte size in epididymal and perirenal WAT than diet-matched controls
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• after 12 wks of HFD feeding, mice show a significantly higher epididymal WAT weight than diet-matched wild-type controls
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• after 12 wks of HFD feeding, mice show a significantly higher perirenal WAT weight than diet-matched wild-type controls
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• after 12 wks of HFD feeding, mice show a significantly higher WAT mass than diet-matched wild-type controls
• however, BAT, liver and kidney weight as well as lean body mass are normal after HFD feeding
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• HFD-fed mice exhibit significantly higher expression of inflammatory markers in WAT than diet-matched wild-type controls
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homeostasis/metabolism
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• HFD-fed mice are glucose intolerant relative to diet-matched wild-type controls
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• HFD-mice are slightly insulin resistant relative to diet-matched wild-type controls
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• dispersed adipocytes isolated from WAT show significantly lower free fatty acid (FFA) and glycerol release than wild-type adipocytes under both basal and stimulated conditions
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immune system
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• HFD-fed mice exhibit significantly higher expression of inflammatory markers in WAT than diet-matched wild-type controls
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