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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rr79em2Rtew
endonuclease-mediated mutation 2, Ryan Tewhey
MGI:7580428
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rr79em2Rtew/Rr79em2Rtew C57BL/6J-Rr79em2Rtew/J MGI:7580547
cx2
 		Rr79em2Rtew/Rr79em2Rtew
Tg(TcraTcrb)1100Mjb/? 		involves: C57BL/6J MGI:7580561


Genotype
MGI:7580547
hm1
Allelic
Composition		 Rr79em2Rtew/Rr79em2Rtew
Genetic
Background		 C57BL/6J-Rr79em2Rtew/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr79em2Rtew mutation (1 available); any Rr79 mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal T cell subpopulation ratio ( J:332957 )
• nave CD8+ T cells have decreased Lef1, Myb, and cell surface CD62L, indicative of decreased restriction into the stem population, with other markers indicative of increased early T cell activation
abnormal T cell physiology ( J:332957 )
• There is decreased expression of genes that suppress T stem cells from activation and functional studies using a co-expressed TCR transgene confirm this

immune system
abnormal T cell subpopulation ratio ( J:332957 )
• nave CD8+ T cells have decreased Lef1, Myb, and cell surface CD62L, indicative of decreased restriction into the stem population, with other markers indicative of increased early T cell activation
abnormal T cell physiology ( J:332957 )
• There is decreased expression of genes that suppress T stem cells from activation and functional studies using a co-expressed TCR transgene confirm this




Genotype
MGI:7580561
cx2
Allelic
Composition		 Rr79em2Rtew/Rr79em2Rtew
Tg(TcraTcrb)1100Mjb/?
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr79em2Rtew mutation (1 available); any Rr79 mutation (1 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal T cell activation ( J:332957 )
• reduced T cell expansion in response to antigen with a higher percentage of terminal effector CD8 cells and lower development of memory T cells

immune system
abnormal T cell activation ( J:332957 )
• reduced T cell expansion in response to antigen with a higher percentage of terminal effector CD8 cells and lower development of memory T cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
07/05/2024
MGI 6.24 		The Jackson Laboratory