About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rr79em2Rtew
endonuclease-mediated mutation 2, Ryan Tewhey
MGI:7580428
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rr79em2Rtew/Rr79em2Rtew C57BL/6J-Rr79em2Rtew/J MGI:7580547
cx2
 		Rr79em2Rtew/Rr79em2Rtew
Tg(TcraTcrb)1100Mjb/? 		involves: C57BL/6J MGI:7580561


Genotype
MGI:7580547
hm1
Allelic
Composition		 Rr79em2Rtew/Rr79em2Rtew
Genetic
Background		 C57BL/6J-Rr79em2Rtew/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr79em2Rtew mutation (1 available); any Rr79 mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal T cell subpopulation ratio ( J:332957 )
• nave CD8+ T cells have decreased Lef1, Myb, and cell surface CD62L, indicative of decreased restriction into the stem population, with other markers indicative of increased early T cell activation
abnormal T cell physiology ( J:332957 )
• There is decreased expression of genes that suppress T stem cells from activation and functional studies using a co-expressed TCR transgene confirm this

immune system
abnormal T cell subpopulation ratio ( J:332957 )
• nave CD8+ T cells have decreased Lef1, Myb, and cell surface CD62L, indicative of decreased restriction into the stem population, with other markers indicative of increased early T cell activation
abnormal T cell physiology ( J:332957 )
• There is decreased expression of genes that suppress T stem cells from activation and functional studies using a co-expressed TCR transgene confirm this




Genotype
MGI:7580561
cx2
Allelic
Composition		 Rr79em2Rtew/Rr79em2Rtew
Tg(TcraTcrb)1100Mjb/?
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr79em2Rtew mutation (1 available); any Rr79 mutation (1 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal T cell activation ( J:332957 )
• reduced T cell expansion in response to antigen with a higher percentage of terminal effector CD8 cells and lower development of memory T cells

immune system
abnormal T cell activation ( J:332957 )
• reduced T cell expansion in response to antigen with a higher percentage of terminal effector CD8 cells and lower development of memory T cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory