Analysis Tools
hearing/vestibular/ear
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• mice exhibit normal organization of utricle hair bundles in both striolar and extrastriolar regions and show no overt vestibular phenotype
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• at P10.5 and P30.5, the shortest row (row 3) of stereocilia is largely missing from the basal region of cochlear OHCs where high frequencies are encoded
• however, ESPN is present at P9 stereocilia tips at similar levels in apical and basal hair bundles
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• at P10.5 and P30.5, basal cochlear OHC bundles only have two rows of stereocilia, except for scattered row 3 stereocilia
• however, all inner hair cells (IHCs) and OHCs from mid regions and the apex appear normal
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• at P30, mice show significantly increased ABR thresholds at 32 kHz relative to wild-type controls
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• at P30, mice show high-frequency hearing loss
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nervous system
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• at P10.5 and P30.5, the shortest row (row 3) of stereocilia is largely missing from the basal region of cochlear OHCs where high frequencies are encoded
• however, ESPN is present at P9 stereocilia tips at similar levels in apical and basal hair bundles
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• at P10.5 and P30.5, basal cochlear OHC bundles only have two rows of stereocilia, except for scattered row 3 stereocilia
• however, all inner hair cells (IHCs) and OHCs from mid regions and the apex appear normal
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