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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Myo3atm1Pgg
targeted mutation 1, Peter G Gillespie
MGI:7581077
Summary 3 genotypes


Genotype
MGI:7610489
hm1
Allelic
Composition		 Myo3atm1Pgg/Myo3atm1Pgg
Genetic
Background		 B6.129-Myo3atm1Pgg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo3atm1Pgg mutation (0 available); any Myo3a mutation (110 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:236347 )
N
• mice exhibit normal hair bundle organization/structure in auditory organs, have normal hearing ABR thresholds at all tested frequencies even at 13 months of age, and show no overt vestibular dysfunction




Genotype
MGI:7610499
cx2
Allelic
Composition		 Myo3atm1Pgg/Myo3atm1Pgg
Myo3btm1Pgg/Myo3btm1Pgg
Genetic
Background		 B6.129-Myo3atm1Pgg Myo3btm1Pgg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo3atm1Pgg mutation (0 available); any Myo3a mutation (110 available)
Myo3btm1Pgg mutation (0 available); any Myo3b mutation (86 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:236347 )
• no mice are born from different crosses designed to generate double homozygotes; mice presumably die during embryonic development




Genotype
MGI:7610500
cx3
Allelic
Composition		 Myo3atm1Pgg/Myo3a+
Myo3btm1Pgg/Myo3btm1Pgg
Genetic
Background		 B6.129-Myo3atm1Pgg Myo3btm1Pgg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo3atm1Pgg mutation (0 available); any Myo3a mutation (110 available)
Myo3btm1Pgg mutation (0 available); any Myo3b mutation (86 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory