Analysis Tools
hearing/vestibular/ear
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• mice exhibit normal hair bundle organization/structure in auditory organs, have normal hearing ABR thresholds at all tested frequencies even at 13 months of age, and show no overt vestibular dysfunction
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• mice show a subtle defect in stereocilia-staircase step spacing in the extrastriolar regions of the utricle, with a significantly smaller length difference between tallest and shortest stereocilia than in Myo3atm1Pgg homozygotes or in wild-type controls
• length difference is mostly to net elongation of short stereocilia; shortening of tall stereocilia is significant but less conspicuous
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nervous system
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• mice show a subtle defect in stereocilia-staircase step spacing in the extrastriolar regions of the utricle, with a significantly smaller length difference between tallest and shortest stereocilia than in Myo3atm1Pgg homozygotes or in wild-type controls
• length difference is mostly to net elongation of short stereocilia; shortening of tall stereocilia is significant but less conspicuous
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